Table 3 Inclusion and exclusion criteria of the D-Vitaal study

- Men and women of ≥60 and ≤80 years

- Presence of major depressive disorder at 

screening

- Presence of depressive symptoms (CES-D ≥16)

- Use of antidepressant medication at screening

- Presence of ≥1 functional limitation

- Presence of major life-threatening illness

- Serum 25(OH)D levels ≤50 (winter) or ≤70 

(summer) nmol/L.

- Vitamin D (>400 IU/day) or calcium (>1000

mg/day) supplementation

- Ability to comply with the study protocol

- Serum 25(OH)D levels <15 nmol/L.

- Living in an institution