Table 2 Previous literature on elderly and DBS surgical complications

Voges et al. (2007)

PD Dystonia ET Others

DBS (nucleus not reported)

<60ys

528

1,9 %

N.r.

N.r.

0.5 %

N.r.

5.5 %

30-days

Age ≥ 60ys and PD risk factors for secondary surgical complications

≥60ys

650

2,5 %

N.r.

N.r.

0,6 %

N.r.

7.7 %

Entire cohort

1,183

2.2 %

0,4 %

N.r.

0.6 %

0.4 %

6.8 %

Derost et al. (2007)

PD

STN-DBS

<65ys

53

None

1.9 %

1.9 %

None

None

3.8 %

2 years

Age ≥65ys is not a surgical risk factor

≥65ys

34

None

None

None

2.9 %

None

2.9 %

Entire cohort

87

None

1.9 %

1.9 %

2.9 %

None

3.4 %

Rughani et al. (2013)

PD, Dystonia ET

DBS (nucleus non reported) Pallidotomy Thalamotomy

Entire cohort (correlation and logistic regression study)

5446

1.9 % risk for patients >70ys

N.r.

N.r.

N.r.

N.r.

3.5 % risk for patients >70ys

/

Age is correlated with in-hospital complications, but appears to serve as a surrogate for comorbidity. Diagnosis of PD carries an increased risk of in-hospital complications.

Shalash et al. (2014)

PD

STN-DBS

≤55ys

29

N.r.

N.r.

17.1 %

N.r.

N.r.

31.0 %

5 years

Age ≥65ys is not a surgical risk factor

56-64ys

52

N.r.

N.r.

7.7 %

N.r.

N.r.

11.6 %

≥65ys

29

N.r.

N.r.

13.8 %

N.r.

N.r..

13.8 %

entire cohort

110

N.r.

N.r.

11.8 %

N.r.

N.r

17.2 %

DeLong et al. (2015)

PD

DBS (nucleus non reported)

Entire cohort (logistic regression study per 5-ys increase)

1757

OR 0.82 (95 % C.I 0.63 1.07) P = 0.14

OR 1.04 (95 % C.I 0.87–1.24) P = 0.69

N.r.

OR 1.28 (95 % CI 0.99–1.64) P = 0,06

N.r

OR 1.10 (95 % C.I 0.96–1.25) P = 0.17

90-days

Age alone should not be a primary exclusion factor for determining candidacy to DBS.

Present study

PD

STN-DBS

<65ys

69

2,9 %

2,9 %

None

None

None

5.8 %

90-days

STN-DBS is a safe surgical procedure both in young and elderly patients

≥65ys

38

7.9 %

None

None

None

None

7.9 %

Entire cohort

107

4.7 %

2.9 %

None

None

None

6.5 %