Table 4 Frequency of NPS and subgroups, ADL functioning and cognition by use of anti-dementia drugs
AChEI only | Memantine only | AChEI and memantine | P-value* | |
|---|---|---|---|---|
n = 465 | n = 145 | n = 181 | ||
Frequency of NPS, n (%) | ||||
None | 202 (43.4) | 60 (41.4) | 58 (32.0) | 0.065 |
One symptom | 144 (31.0) | 47 (32.4) | 61 (33.7) | 0.569 |
Two to three symptoms | 97 (20.9) | 28 (19.3) | 46 (25.4) | 0.296 |
Four or more symptoms | 22 (4.7) | 10 (6.9) | 16 (8.8) | 0.107 |
Any NPD, n (%) | 263 (56.6) | 85 (58.6) | 123 (68.0) | 0.029 |
Subgroups, n (%) | ||||
Hyperactivity | 136 (29.2) | 45 (31.0) | 83 (45.9) | |
Psychosis | 54 (11.6) | 18 (12.4) | 33 (18.2) | |
Mood symptoms and apathy | 170 (36.6) | 57 (39.3) | 72 (39.8) | |
ADL score, mean (SD) | 62.3 (31.5) | 48.0 (31.7) | 54.6 (28.9) | <0.001 |
MMSE, mean (SD) | 17.2 (6.3) | 14.4 (7.2) | 13.9 (6.2) | <0.001 |