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Table 3 Odds ratio from logistic regression relationship between levels of soluble VCAM-1 and depression symptoms (CESD-R score ≥16), No. = 668†

From: Elevated circulating vascular cell Adhesion Molecule-1 (sVCAM-1) is associated with concurrent depressive symptoms and cerebral white matter Hyperintensities in older adults

  Quintiles of sVCAM-1, Median (IQR), ng/mL P for trend
  736 (660–810) 937 (899–970) 1115 (1071–1169) 1332 (1277–1389) 1711 (1567–2011)
No. 132 135 135 132 134  
Model 1       
Odds ratio (95 % CI) 1.00 1.58 (0.88-2.82) 1.68 (0.94-2.97) 1.59 (0.89-2.83) 2.18 (1.24-3.84)  
P value Reference 0.13 0.08 0.12 0.0066 0.011
Model 2       
Odds ratio (95 % CI) 1.00 1.59 (0.89-2.86) 1.61 (0.90-2.87) 1.53 (0.85-2.74) 1.96 (1.09-3.51)  
P value Reference 0.12 0.10 0.15 0.024 0.025
Model 3       
Odds ratio (95 % CI) 1.00 1.69 (0.93-3.08) 1.62 (0.90-2.92) 1.55 (0.85-2.82) 2.10 (1.17-3.78)  
P value Reference 0.12 0.11 0.15 0.024 0.026
Model 4       
Odds ratio (95 % CI) 1.00 1.79 (0.95-3.39) 1.65 (0.88-3.07) 1.68 (0.89-3.17) 1.97 (1.14-3.57)  
P value Reference 0.07 0.12 0.11 0.015 0.030
  1. sVCAM-1: Soluble Vascular Cell Adhesion Molecule-1; CI, confidence interval; IQR, interquartile range.
  2. †Missing values = 12 from 680; Model 1: non adjusted; Model 2: adjusted for Biomarkers ( IL6, C-Reactive Protein); Model 3: additionally adjusted for Socio-demographic condition (Age, gender, White race, Body Mass Index, Current Smoker, Alcohol use, physical activity); Model 4: additionally adjusted for Health conditions (Diabetes, Hypertension, Congestive Heart failure, Cognitive status, Any cardiovascular medications, Coronary disease, Previous stroke, any cardiovascular medication and psychotropic medication)