Elevated circulating vascular cell Adhesion Molecule-1 (sVCAM-1) is associated with concurrent depressive symptoms and cerebral white matter Hyperintensities in older adults

Table 3 Odds ratio from logistic regression relationship between levels of soluble VCAM-1 and depression symptoms (CESD-R score ≥16), No. = 668†

	Quintiles of sVCAM-1^‡, Median (IQR), ng/mL					P for trend
	736 (660–810)	937 (899–970)	1115 (1071–1169)	1332 (1277–1389)	1711 (1567–2011)	P for trend
No.	132	135	135	132	134
Model 1
Odds ratio (95 % CI)	1.00	1.58 (0.88-2.82)	1.68 (0.94-2.97)	1.59 (0.89-2.83)	2.18 (1.24-3.84)
P value	Reference	0.13	0.08	0.12	0.0066	0.011
Model 2
Odds ratio (95 % CI)	1.00	1.59 (0.89-2.86)	1.61 (0.90-2.87)	1.53 (0.85-2.74)	1.96 (1.09-3.51)
P value	Reference	0.12	0.10	0.15	0.024	0.025
Model 3
Odds ratio (95 % CI)	1.00	1.69 (0.93-3.08)	1.62 (0.90-2.92)	1.55 (0.85-2.82)	2.10 (1.17-3.78)
P value	Reference	0.12	0.11	0.15	0.024	0.026
Model 4
Odds ratio (95 % CI)	1.00	1.79 (0.95-3.39)	1.65 (0.88-3.07)	1.68 (0.89-3.17)	1.97 (1.14-3.57)
P value	Reference	0.07	0.12	0.11	0.015	0.030

^‡sVCAM-1: Soluble Vascular Cell Adhesion Molecule-1; CI, confidence interval; IQR, interquartile range.
†Missing values = 12 from 680; Model 1: non adjusted; Model 2: adjusted for Biomarkers ( IL6, C-Reactive Protein); Model 3: additionally adjusted for Socio-demographic condition (Age, gender, White race, Body Mass Index, Current Smoker, Alcohol use, physical activity); Model 4: additionally adjusted for Health conditions (Diabetes, Hypertension, Congestive Heart failure, Cognitive status, Any cardiovascular medications, Coronary disease, Previous stroke, any cardiovascular medication and psychotropic medication)

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