Table 2 Cut-offs indicating probable vitamin B12 deficiency, probable vitamin B12 sufficiency and a grey zone of diagnostic uncertainty. These cut-offs are given for four markers of vitamin B12 status and were obtained by ROC-analysisÂ
| Â | Probable vitamin B12 deficiency | Grey zone | Probable vitamin B12 sufficiency |
|---|---|---|---|
Vitamin B12 (pmol/L) | <131 | 131 – 315 | ≥316 |
Holotranscobalamin (pmol/L) | <25.8 | 25.8 – 56.9 | ≥57.0 |
MMA (nmol/L) | >485 | 217 – 485 | ≤216 |
Homocysteine (μmol/L) | >26.8 | 9.6 – 26.8 | ≤9.5 |