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Table 1 Baseline characteristics. The parameters given are associated with markers of vitamin B12 and folic acid status and are classified according to three different age groups. P-values are given for differences among the three different groups

From: Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits

 

60-69 yrs

70-79 yrs

≥80 yrs

P values+

Female/Male (n)

278/237

247/188

112/81

0.53

Hb (g/L)

143.00 (136.00, 151.00); n = 515

142 (134, 149.00); n = 435

139 (131.00, 146.00); n = 193

<0.001

MCV (fl)

89.00 (87.00, 91.00); n = 515

90.00 (87.00, 92.00); n = 435

91.00 (88.00, 93.00); n = 193

<0.001

Fedosov’s ω

0.13 (−0.13, 0.36); n = 463

0.02 (−0.30, 0.33); n = 411

−0.10 (−0.39, 0.22); n = 184

<0.001

B12 (pmol/L)

237 (190, 292); n = 515

228 (180.00, 292); n = 435

231 (185, 301); n = 193

0.22

holoTc (pmol/L)

52.3 (41.0, 66.0); n = 508

54.1 (39.3, 69.0); n = 432

51.8 (38.2, 67.3); n = 193

0.60

MMA (nmol/L)

207 (169, 261.00); n = 467

221 (179, 294); n = 412

244 (190, 326); n = 184

<0.001

Hcy (μmol/L)

12.5 (10.5, 14.80); n = 515

13.9 (11.6, 16.7); n = 435

15.5 (12.8, 19.9); n = 193

<0.001

Serum folate (nmol/L)

19.5 (13.8, 27.0); n = 515

17.7 (12.9; 25.3); n = 4354

17.2 (13.0, 25.3); n = 193

0.01

Red cell folate (nmol/L)

899 (700,1157); n = 498

870 (669,1157); n = 431

837 (646, 1136); n = 192

0.17

Folate/B12

83.4 (58.9, 116.3); n = 515

81.5 (55.9, 112.0); n = 435

76.8 (57.3, 104.5); n = 139

0.09

eGFR (ml/min/1.73 m2)

90 (82, 98); n = 515

82 (69, 89); n = 435

67 (54, 78); n = 193

<0.001

Mentzer index

18.70 (17.60, 19.79); n = 515

18.94 (17.77, 20.22); n = 435

20.0 (18.33, 21.09); n = 193

<0.001

  1. Footnote: Values are median and interquartile range (IQR) for continuous variables. n = number
  2. +Kruskal-Wallis test for continuous variables; chi square test for proportion female/male