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Table 2 Multivariable associations between participant characteristics and measured or perceived frailty

From: Perceived frailty and measured frailty among adults undergoing hemodialysis: a cross-sectional analysis

 

Odds ratio (95% CI)a

Measured frailty

Nephrologist-perceived frailty

NP-perceived frailty

Patient-perceived frailty

Age (per 5-yr increase)

1.08 (0.95-1.24)

1.36 (1.11-1.68)

1.07 (0.76-1.51)

0.81 (0.70-0.95)

Being a woman

1.34 (0.71-2.53)

1.74 (0.91-3.31)

2.25 (0.82-6.21)

1.18 (0.57-2.42)

Non-African American race

1.72 (0.71-4.17)

1.30 (0.79-2.16)

5.51 (3.21-9.48)

4.20 (1.61-10.9)

Post-secondary education

  

0.37 (0.31-0.45)

 

Currently employed

  

0.16 (0.05-0.53)

 

History of smoking

 

3.05 (1.28-7.29)

 

3.69 (1.54-8.81)

Obese

1.27 (0.65-2.47)

0.21 (0.16-0.29)

0.44 (0.27-0.72)

 

Comorbiditiesb

1.07 (0.83-1.38)

1.49 (1.27-1.75)

1.23 (0.73-2.06)

1.29 (0.97-1.72)

Disabilityc

1.47 (1.04-2.08)

1.26 (0.70-2.24)

1.97 (0.63-6.18)

1.43 (1.02-1.99)

Frailty

    

 Non frail

-

ref

ref

ref

 Intermediately frail

-

1.21 (0.53-2.78)

6.23 (2.35-16.5)

2.06 (0.79-5.36)

 Frail

-

2.77 (0.87-8.83)

4.19 (0.92-19.1)

1.28 (0.50-3.30)

  1. Abbreviations: NP Nurse Practitioner, CI confidence interval.
  2. a95% CIs for the for neprhologist-perceived frailty and NP-perceived frailty were estimated allowing for intragroup correlation because the same nephrologist or NP was able to rate multiple participants.
  3. bper one comorbidity increase.
  4. cper reported increase in difficulty with one activity of daily living (ADL).
  5. Bold indicates significance at the P<0.05 level.
  6. Odds ratios were estimated using ordered logistic regression with an order of non-frail, intermediately frail, and frail. Under the proportional odds assumption, the estimated odds ratio applies to either of the two odds ratios being modeled: for example, participants who reported difficulty with one ADL were 1.47-fold more likely to be intermediately frail or frail compared to non-frail and 1.47-fold more likely to be frail compared to intermediately frail or non-frail relative to participants who reported no difficulty for any ADL.