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Table 3 Microcirculatory evaluation (NVC) and vasoreactivity analysis (VOP)

From: Relationship between biomarkers of inflammation, oxidative stress and endothelial/microcirculatory function in successful aging versus healthy youth: a transversal study

 

Young Controls (n = 24)

Healthy Elderly (n = 11)

p value

NVC FCD (number of capillaries/mm2)

13.6 [12.6-14.9]

12.8 [11.9-13.7]

0.100

AFD (μm)

8.5 [6.1-11.2]

15.4 [13.7-16.3]*

< 0.01

APD (μm)

8.7 [7.1-10.7]

15.3 [13.6-17.0]*

< 0.01

EFD (μm)

8.7 [7.2-12.0]

14.9 [14.3-16.2]*

< 0.01

RBCVbasal

0.24 [0.22-0.28]

0.29 [0.29-0.30]*

< 0.05

RBCVmax

0.35 [0.33-0.39]

0.35 [0.34-0.36]

0.616

RBCVmax/RBCVbas

1.35 [1.21-1.79]

1.23 [1.17-1.26]*

< 0.05

Time to reach RBCVmax/RBCVbas (s)

5 [4-6]

4 [4-6]

0.408

VOP

   

% Hyper

606 [508-744]

316 [256-465]*

< 0.001

% Nitro

208 [122-257]

187 [130-202]

0.530

  1. FCD = Functional Capillary Density; Afferent, Apical and efferent capillary diameters (AFD,APD and EFD); RBCVmax/RBCVbas = increment of maximum red blood cell velocity (RBCVmax) related to RBCV at baseline; % Hyper = percent of increment of forearm blood flow during reactive hyperemia related to baseline; % Nitro = increment of forearm blood flow after sublingual spray of nitroglycerine related to baseline. *p < 0.05 or p < 0.01 related to young controls.