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Table 1 Characteristics of included studies

From: A meta-analysis of prospective studies on the role of physical activity and the prevention of Alzheimer’s disease in older adults

Study Sample size (n) Mean Length of Follow-up (years) Number of Alzheimer’s cases Log HR/RR Log 95% C.I. Mean age of study participants mean (SD) %APOE (% tested positive for the APOE gene) Gender (F) Measurement of physical activity
Scarmeas et al. [13] 1880 5.4 282 −0.46 (−0.82, −0.11) 77.2 (6.6) 24% n = 443 69% n = 1293 Godin-time leisure questionnaire
Buchman et al. [8] 716 4 71 −0.63 (−1.22, −0.05) 81.6 (7.12) n/a 76% n = 602 Actigraphs worn by participants
Scarmeas et al. [14] 4166 5.2 262 −0.73 (−1.27, −0.20) Alzheimer’s disease patients 78.8 (6.7) Alzheimer’s disease patients, much PA: 33% n = 33 No PA: 33% n = 40 Alzheimer’s disease patients, Much Physical activity: 66% n = 71, No Physical activity: 71% n = 102 Godin-time leisure questionnaire
Larson et al. [15] 1740 6.2 107 −0.37 (−0.79, 0.05) Participants who exercised fewer than 3x week: 74.5 (5.8) Participants who exercised more than 3x week: 74.3 (5.7) Participants who exercised fewer than 3x week: 23% n = 100 Participants who exercised more than 3x week: 22% n = 290 Participants who exercised fewer than 3x week: 63% n = 278 Participants who exercised more than 3x week: 60% n = 772 Self-reported, regular exercise defined as “three times a week or more”
Lindsay et al. [12] 4615 5.0 194 −0.37 (−0.70, −0.04) Alzheimer’s disease cases, 81 (sd n/a) 40% n = 39/98 cases tested 68% n = 131 Participation in regular exercise “yes/no”
Podewils et al. [7] 3375 5.4 245 −0.36 (−0.83, 0.11) 74.8 (4.9) 24% n = 813 59% n = 1,995 Minnesota Leisure time activity questionnaire
Abbott et al. [16] 2257 6.0 101 −0.80 (−1.54, −0.06) Participants who walked more than 2 miles per day: 76 (3.6) Participants who walked less than 0.25 miles per day: 77.4 (4.4) Participants who walked more than 2 miles per day: 17% n = 78 Participants who walked less than 0.25 miles per day: 19% n = 105 0% Physical Activity Index
Yoshitake et al. [17] 828 7.0 42 −1.71 (−2.94, −0.49) Men: 73 (5.6) Women: 74 (6.1) n/a 60% n = 493 Categorized self-reported physical activity levels
Ravaglia et al. [18] 749 3.9 54 −0.36 (−1.11, 0.40) 73.2 (6.0) 16% n = 123 54% n = 401 Paffenbarger physical activity questionnaire