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Table 4 Risk of Fall in Occasional and Regular Users of Inappropriate Medication compared to Never Users

From: Inappropriate medication use and risk of falls – A prospective study in a large community-dwelling elderly cohort

  ≤ 1 fall ≥ 2 falls     
Medication n (%) (N = 4961) (N = 1382) OR (95% CI) crude P-Value OR (95% CI)*† P-Value†
Inappropriate medication full list       
   Occasional user‡ 809 (16) 277 (20) 1.48 (1.26–1.74) <.001 1.23 (1.04–1.45) .016
   Regular user § 1389 (28) 465 (34) 1.45 (1.26–1.66) <.001 1.08 (0.94–1.25) .29
Inappropriate medication without cerebral vasodilators       
   Occasional user 704 (14) 239 (17) 1.38 (1.17–1.63) <.001 1.22 (1.02–1.45) .030
   Regular user 826 (17) 300 (22) 1.48 (1.27–1.72) <.001 1.19 (1.00–1.41) .049
Long-acting benzodiazepines       
   Occasional user 286 (9) 117 (13) 1.58 (1.26–1.98) <.001 1.40 (1.10–1.79) .006
   Regular user 316 (9) 135 (15) 1.65 (1.33–2.04) <.001 1.41 (1.12–1.79) .004
Inappropriate psychotropic drugs       
   Occasional user 102 (2) 37 (3) 1.33 (0.91–1.95) .14 1.17 (0.74–1.83) .50
   Regular user 74 (1) 39 (3) 1.93 (1.30–2.86) .001 1.74 (1.14–2.66) .010
Inappropriate medication with anticholinergic properties       
   Occasional user 264 (5) 91 (7) 1.29 (1.01–1.65) .042 1.21 (0.93–1.58) .15
   Regular user 172 (3) 84 (6) 1.83 (1.40–2.40) <.001 1.57 (1.18–2.10) .002
Short- or intermediate-half-life benzodiazepines       
   Occasional user 429 (9) 151 (11) 1.34 (1.10–1.63) .004 1.20 (0.96–1.49) .11
   Regular user 441 (9) 153 (11) 1.32 (1.08–1.60) .006 1.05 (0.83–1.32) .69
  1. * Reference group: Never user of inappropriate medication
  2. ‡ Occasional user: exposure at only one of the 3 examinations (baseline and 2 follow-up)
  3. §Regular user: exposure at two or three examinations
  4. † Adjusted for age, sex, study centre, Body Mass Index, diurnal drowsiness, number of drugs (excluding IM), cognitive functioning, depressive symptoms and impaired mobility.
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