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Table 3 The association of functional disability with subcortical measure of neurodegeneration.

From: Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study

  Unadjusted Odds Ratio (95% CI) Adjusted Odds Ratio (95% CI)
  Mild   Severe   Mild   Severe  
Sex         
Men 1.00   1.00   1.00   1.00  
Women 2.3 (0.9–5.4) 1.9 (0.9–4.1) 3.4 (0.9–12.9) 1.4 (0.5–4.2)
Age at death         
<75 1.00   1.00   1.00   1.00  
75–84 1.3 (0.4–4.1) 0.7 (0.2–1.9) 1.2 (0.2–7.0) 0.3 (0.1–1.4)
>84 3.3 (1.0–10.9) 4.2 (1.5–12.1) 2.9 (0.5–16.2) 2.4 (1.0–9.2)
Overall effect* 1.7 (1.0–3.0) 2.3 (1.4–3.8) 1.6 (0.7–3.5) 1.7 (0.9–3.2)
SUBCORTICAL PATHOLOGY (Factor present reference absence)
NFT 2.1 (0.8–5.0) 1.6 (0.8–3.6)     
Neuronal loss 1.3 (0.5–3.2) 3.0 (1.3–6.6) 1.4 (0.3–5.4) 3.9 (1.2–12.5)
Plaques 0.6 (0.1–2.2) 0.3 (0.1–1.2)     
Vascular disease 2.2 (0.2–24.9) 3.3 (0.4–29.1)     
Lewy bodies 8.3 (0.9–78.3) 1.8 (0.2–18.6) 8.1 (0.8–87.2) 1.2 (0.1–14.2)
LB in Substantia nigra   Impossible to calculate; 100% predictive
  1. 2 test for trend Adjusted for all other effects in the table.