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Table 3 The association of functional disability with subcortical measure of neurodegeneration.

From: Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study

 

Unadjusted Odds Ratio (95% CI)

Adjusted Odds Ratio (95% CI)

 

Mild

 

Severe

 

Mild

 

Severe

 

Sex

        

Men

1.00

 

1.00

 

1.00

 

1.00

 

Women

2.3

(0.9–5.4)

1.9

(0.9–4.1)

3.4

(0.9–12.9)

1.4

(0.5–4.2)

Age at death

        

<75

1.00

 

1.00

 

1.00

 

1.00

 

75–84

1.3

(0.4–4.1)

0.7

(0.2–1.9)

1.2

(0.2–7.0)

0.3

(0.1–1.4)

>84

3.3

(1.0–10.9)

4.2

(1.5–12.1)

2.9

(0.5–16.2)

2.4

(1.0–9.2)

Overall effect*

1.7

(1.0–3.0)

2.3

(1.4–3.8)

1.6

(0.7–3.5)

1.7

(0.9–3.2)

SUBCORTICAL PATHOLOGY (Factor present reference absence)

NFT

2.1

(0.8–5.0)

1.6

(0.8–3.6)

    

Neuronal loss

1.3

(0.5–3.2)

3.0

(1.3–6.6)

1.4

(0.3–5.4)

3.9

(1.2–12.5)

Plaques

0.6

(0.1–2.2)

0.3

(0.1–1.2)

    

Vascular disease

2.2

(0.2–24.9)

3.3

(0.4–29.1)

    

Lewy bodies

8.3

(0.9–78.3)

1.8

(0.2–18.6)

8.1

(0.8–87.2)

1.2

(0.1–14.2)

LB in Substantia nigra

 

Impossible to calculate; 100% predictive

  1. 2 test for trend Adjusted for all other effects in the table.