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Table 5 Sex-related decrease of IGF-1.

From: A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study

 

Age bracket

(no. of people)

plasma IGF-1 [ng/mL]

(mean ± SD)

Males (n = 264)

  

5 years

70–75 (49)

213 ± 88

 

76–80 (66)

204 ± 76

 

81–85 (50)

200 ± 81

 

86–90 (32)

157 ± 65 **

 

>90 (67)

159 ± 74 **

10 years

70–79 (99)

212 ± 83

 

80–89 (85)

189 ± 76

 

90–99 (79)

158 ± 72 §

 

>99 (1)

63

Females (n = 300)

  

5 years

70–75 (54)

175 ± 70

 

76–80 (53)

189 ± 104

 

81–85 (46)

164 ± 64

 

86–90 (43)

161 ± 70

 

>90 (104)

170 ± 73

10 years

70–79 (96)

185 ± 91

 

80–89 (92)

159 ± 59

 

90–99 (107)

173 ± 76

 

>99 (5)

142 ± 86

Total subjects (n = 564)

  

M (n = 264)

 

188 ± 80

F (n = 300)

 

172 ± 77#

  1. **p < 0.01 vs. male (70–75) group; §p <0.01 vs. male (70–79) group; #p < 0.05 vs. total male subjects (n = 264), one-way ANOVA followed by Dunnett's post-hoc test. SD: standard deviation.