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Table 5 Sex-related decrease of IGF-1.

From: A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study

  Age bracket (no. of people) plasma IGF-1 [ng/mL] (mean ± SD)
Males (n = 264)   
5 years 70–75 (49) 213 ± 88
  76–80 (66) 204 ± 76
  81–85 (50) 200 ± 81
  86–90 (32) 157 ± 65 **
  >90 (67) 159 ± 74 **
10 years 70–79 (99) 212 ± 83
  80–89 (85) 189 ± 76
  90–99 (79) 158 ± 72 §
  >99 (1) 63
Females (n = 300)   
5 years 70–75 (54) 175 ± 70
  76–80 (53) 189 ± 104
  81–85 (46) 164 ± 64
  86–90 (43) 161 ± 70
  >90 (104) 170 ± 73
10 years 70–79 (96) 185 ± 91
  80–89 (92) 159 ± 59
  90–99 (107) 173 ± 76
  >99 (5) 142 ± 86
Total subjects (n = 564)   
M (n = 264)   188 ± 80
F (n = 300)   172 ± 77#
  1. **p < 0.01 vs. male (70–75) group; §p <0.01 vs. male (70–79) group; #p < 0.05 vs. total male subjects (n = 264), one-way ANOVA followed by Dunnett's post-hoc test. SD: standard deviation.