A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the

Table 2 rs2229765 genotypic and allelic frequencies according to age and sex.

	Genotype count (%)			Allele count (%)
Age bracket (no. of people)	G/G	G/A	A/A	G	A	χ² p-value (genotypic distribution)	χ² p-value (allelic distribution)
70–85 (288)	102 (35.4)	147 (51.1)	39 (13.5)	351 (61.0)	225 (39.0)
M (147)	59(40.0)	75 (51.0)	13 (9.0)	193 (65.6)	101 (34.4)
F (141)	43 (30.5)	72 (51.0)	26 (18.5)^a	158 (56.0)	124 (44.0)^b	^ap = 0.03	^b p = 0.02
85+ (222)	70 (31.5)	110 (49.5)	42 (19.0)	250 (56.3)	194 (43.7)
M (89)	26 (29.2)	48 (53.9)	15 (16.8)	100 (56.2)	78 (43.7)^c		^c p = 0.04
F (133)	44 (33.1)	62 (46.6)	27 (20.4)^d	150 (56.4)	116 (43.6)^e	^d p = 0.02	^e p = 0.02

^a: χ² p-value for the comparison of the genotype count distribution between males 70–85 and females 70–85; ^b: χ² p-value for the comparison of the allele count distribution between males 70–85 and females 70–85; ^c: χ² p-value for the comparison of the allele count distribution between males 70–85 and males 85+; ^d: χ² p-value for the comparison of the genotype count distribution between males 70–85 and females 85+; ^e: χ² p-value for the comparison of the allele count distribution between males 70–85 and females 85+.
M: men, F: women.

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