Table 2 Risk of AD with and without prior use of NSAIDs, stratified by APOE-ε4 carrier status
From: Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
EXPOSURE | AD (N = 691) | NON-DEMENTED FAMILY MEMBERS (N = 973) | CRUDE ODDS RATIO (95% CI) | AGE-ADJUSTED ODDS RATIO (95% CI) | ADJUSTED ODDS RATIO (95% CI) |
|---|---|---|---|---|---|
Overall | |||||
No NSAIDs | 667 | 907 | 1.0 | 1.0 | 1.0 |
Use of NSAIDs | 24 | 66 | 0.49 (0.31, 0.80) | 0.55 (0.34, 0.88) | 0.64 (0.38, 1.05)* |
Having no ε4 alleles | |||||
No NSAIDs | 231 | 556 | 1.0 | 1.0 | 1.0 |
Use of NSAIDs | 12 | 47 | 0.61 (0.32, 1.18) | 0.75 (0.38, 1.46) | 0.78 (0.39, 1.52)** |
Having at least one ε4 allele | |||||
No NSAIDs | 436 | 351 | 1.0 | 1.0 | 1.0 |
Use of NSAIDs | 12 | 19 | 0.51 (0.24, 1.06) | 0.47 (0.24, 0.96) | 0.49 (0.24, 0.98)** |