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Table 2 Risk of AD with and without prior use of NSAIDs, stratified by APOE-ε4 carrier status

From: Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study

EXPOSURE AD (N = 691) NON-DEMENTED FAMILY MEMBERS (N = 973) CRUDE ODDS RATIO (95% CI) AGE-ADJUSTED ODDS RATIO (95% CI) ADJUSTED ODDS RATIO (95% CI)
Overall      
No NSAIDs 667 907 1.0 1.0 1.0
Use of NSAIDs 24 66 0.49 (0.31, 0.80) 0.55 (0.34, 0.88) 0.64 (0.38, 1.05)*
Having no ε4 alleles      
No NSAIDs 231 556 1.0 1.0 1.0
Use of NSAIDs 12 47 0.61 (0.32, 1.18) 0.75 (0.38, 1.46) 0.78 (0.39, 1.52)**
Having at least one ε4 allele      
No NSAIDs 436 351 1.0 1.0 1.0
Use of NSAIDs 12 19 0.51 (0.24, 1.06) 0.47 (0.24, 0.96) 0.49 (0.24, 0.98)**
  1. *Adjusted for age, sex, ethnicity, education, and APOE-ε4 status.
  2. **Adjusted for age, sex, ethnicity, and education.
  3. ***NSAID*APOE-ε4 interaction p-value = 0.04.