Table 2 Efficacy outcome measures
Outcome measure | Mean baseline score | Mean change (SE) | ||
|---|---|---|---|---|
Week 6 | Week 28 | Week 52 | ||
CGI-Severity | 4.51 | -2.08 (0.11)** | -2.93 (0.12)** | -3.15 (0.12)** |
PGI-Improvement | N/A | 2.33 (0.14)** | 1.83 (0.16)** | 1.84 (0.16)** |
HAMD 17 Total Score | 21.8 | -13.0 (0.7)** | -17.4 (0.8)** | -17.5 (0.8)** |
Anxiety subscale | 6.70 | -3.46 (0.30)** | -4.89 (0.33)** | -4.90 (0.34)** |
Core subscale | 8.83 | -5.65 (0.33)** | -7.50 (0.36)** | -7.61 (0.38)** |
Maier subscale | 10.7 | -6.64 (0.38)** | -8.90 (0.42)** | -9.06 (0.44)** |
Retardation subscale | 7.84 | -4.49 (0.27)** | -6.58 (0.30)** | -6.49 (0.31)** |
Sleep subscale | 3.68 | -2.34 (0.21)** | -2.84 (0.23)** | -2.83 (0.24)** |
HAMD17 Item 1 | 2.64 | -1.73 (0.11)** | -2.30 (0.13)** | -2.30 (0.13)** |
HAMD17 Item 3 | 0.74 | -0.58 (0.06)** | -0.59 (0.06)** | -0.61 (0.06)** |
BDI-II Total Score | 29.5 | -15.8 (1.0)** | -22.3 (1.1)** | -22.0 (1.1)** |
Sheehan Disability Scale | ||||
Work item | 6.91 | -3.01 (0.32)** | -4.60 (0.37)** | -4.27 (0.39)** |
Family item | 6.82 | -3.63 (0.32)** | -4.88 (0.35)** | -4.95 (0.37)** |
Social item | 7.27 | -3.45 (0.34)** | -4.57 (0.38)** | -4.85 (0.40)** |