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Table 2 Validity of Mindstreams tests in discriminating participants with mild cognitive impairment (MCI; N = 30) from cognitively healthy elderly (N = 39).

From: Validity of a novel computerized cognitive battery for mild cognitive impairment

Cognitive Domain

Mindstreams Test (outcome parameter)

AUC

SE

Asymptotic Significance

95% CI

MEMORY

Verbal Memory (accuracy, first repetition trial)

0.779

0.057

0.000

0.668–0.890

 

Verbal Memory (accuracy, second repetition trial)

0.838

0.05

0.000

0.741–0.936

 

Verbal Memory (accuracy, third repetition trial)

0.752

0.063

0.000

0.629–0.876

 

Verbal Memory Accuracy (accuracy, final repetition trial)

0.783

0.062

0.000

0.662–0.904

 

Verbal Memory (accuracy, all repetition trials)

0.859

0.048

0.000

0.765–0.953

 

Verbal Memory (accuracy, delayed recognition)

0.771

0.061

0.000

0.651–0.890

 

Non-Verbal Memory (accuracy, first repetition trial)

0.654

0.067

0.033

0.522–0.786

 

Non-Verbal Memory (accuracy, second repetition trial)

0.698

0.069

0.006

0.563–0.833

 

Non-Verbal Memory (accuracy, third repetition trial)

0.712

0.065

0.003

0.585–0.839

 

Non-Verbal Memory Accuracy (accuracy, final repetition trial)

0.773

0.061

0.000

0.654–0.892

 

Non-Verbal Memory (accuracy, all repetition trials)

0.756

0.063

0.000

0.633–0.879

 

Non-Verbal Memory (accuracy, delayed recognition)

0.728

0.065

0.002

0.601–0.854

EXECUTIVE FUNCTION

Go-NoGo (accuracy)

0.736

0.065

0.001

0.608–0.863

 

Go-NoGo (performance index)

0.810

0.056

0.000

0.701–0.920

 

Problem Solving (accuracy)

0.768

0.059

0.000

0.653–0.884

 

Stroop Interference (performance index)

0.703

0.077

0.023

0.551–0.854

 

Catch Game (accuracy)

0.696

0.075

0.016

0.548–0.843

VISUAL SPATIAL

Visual Spatial Imagery (accuracy)

0.765

0.060

0.000

0.648–0.881

VERBAL

Verbal Function (accuracy, naming)

0.716

0.067

0.005

0.584–0.848

 

Verbal Function (accuracy, rhyming)

0.824

0.051

0.000

0.724–0.923

ATTENTION

Go-NoGo (RT)

0.771

0.063

0.000

0.648–0.893

 

Go-NoGo (standard deviation of RT)

0.706

0.066

0.006

0.576–0.835

 

Choice Reaction Time (performance index)

0.490

0.084

0.894

0.326–0.653

INFORMATION PROCESSING

Staged Information Processing, Low Load (performance index)

0.579

0.083

0.345

0.416–0.743

 

Staged Information Processing, Medium Load (performance index)

0.783

0.070

0.001

0.646–0.920

 

Staged Information Processing, High Load (performance index)

0.688

0.088

0.037

0.515–0.860

MOTOR SKILLS

Finger Tapping (inter-tap interval)

0.595

0.076

0.215

0.446–0.744

 

Finger Tapping (standard deviation of inter-tap interval)

0.625

0.080

0.101

0.469–0.782

 

Catch Game (time to first move)

0.521

0.082

0.797

0.360–0.682

  1. Mindstreams outcome parameters with insufficient data (<13 data points per group) due to failed practice sessions (see Methods) were excluded. AUC = area under the curve SE = standard error CI = confidence interval RT = reaction time