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Table 9 Number of studies of cognition and muscle size, direction of effect and number of subjects

From: A systematic review of the evidence that brain structure is related to muscle structure and their relationship to brain and muscle function in humans over the lifecourse

 

Negative association (n)

No association (n)

Positive association (n)

References

Muscle size and global cognitive score

-

3 (193)

-

[27, 28, 72]

Muscle size and MMSE

-

5 (1434)h,i

2 (3459)h

[28, 65, 66, 68, 73, 75]

Muscle size and California Verbal Learning Test

-

1 (786)

-

[76]

Muscle size and CSI-D

-

1 (3153)

-

[68]

Muscle size and digit span

-

2 (815)j

-

[74, 76]

Muscle size and Kaufman Brief Intelligence Test

-

1 (139)

-

[77, 78]

Muscle size and modified Stroop test

-

1 (48)

-

[65]

Muscle size and NART

1 (51)

-

-

[27]

Muscle size and TMT-a

-

3 (887)

-

[72, 74, 76]

Muscle size and TMT-b

-

3 (887)

-

[72, 74, 76]

  1. hLeg LM was associated with muscle size but not total LM or arm LM in this study [66].
  2. iIn an MLR there was no association between MMSE and FFM but when comparing subjects with normal RASM and those within the lowest 20% of RASM this study found a significant difference [75].
  3. jDigit span forwards unadjusted and adjusted was not associated with thigh muscle CSA, but adjusted backwards digit span was negatively associated with thigh muscle CSA in this study [76].