Table 8 Number of studies of brain structure and gait speed, direction of effect and number of subjects

Gait speed and whole brain volume

-

-

2 (885)

[58, 59, 61]

Gait speed and WM volume

-

2 (1587)

3 (813) ^b

[42, 48–50, 61]

Gait speed and GM volume

-

4 (2449) ^c

3 (367) ^b,d

[43, 47–50, 54, 61]

Gait speed and hippocampal volume

-

1 (191)

-

[58, 59]

Gait speed and cerebellar volume

-

1 (111)

-

[38]

Gait speed and WMH volume

7 (7145) ^e

4 (278) ^e,f

-

[45, 46, 49, 50, 52, 53, 56–61, 64]

Gait speed and CSF volume/ventricular volume/brain atrophy

3 (3221) ^g

2 (1489) ^g

-

[50, 56, 57, 60, 61]

Gait speed and WMH progression over f/u

-

1 (14)

-

[52]

Change in gait speed over f/u and whole brain volume

-

1 (694)

-

[61]

Change in gait speed over f/u and WM volume

-

2 (1622)

-

[42, 61]

Change in gait speed over f/u and GM volume

-

1 (694)

-

[61]

Change in gait speed over f/u and CSF/ventricular volume

-

1 (694)

1 (2450)

[57, 61]

Change in gait speed over f/u and WMH volume

-

1 (694)

2 (4152)

[45, 57, 61]

Change in gait speed over f/u and WM atrophy

-

-

1 (225)

[39]

Change in gait speed over f/u and GM atrophy

-

1 (225)

-

[39]

Change in gait speed over f/u and hippocampal atrophy

-

-

1 (225)

[39]

Change in gait speed over f/u and WMH progression

-

1 (77)

1 (225)

[39, 50]