Table 4 Model 2: Effects of cognitive impairment (CDR sum of boxes) measured at four time points on P-ADL level at the same time points estimated by linear mixed model with random effects for intercepts and time

Effect of main variables ¹

Time

0.06 (0.02; 0.10)

0.002

0.18 (0.14; 0.22)

<0.001

Time* time

0.001 (-0.001; -0.001)

<0.001

-0.001 (-0.001; -0.0004)

<0.001

CDR sum of boxes (at 4 time points)

0.48 (0.43; 0.54)

<0.001

0.60 (0.52; 0.67)

<0.001

Time* CDR sum of boxes

0.003 (0.001; 0.006)

0.007

-0.003 (-0.006; -0.0006)

0.019

Effect of additional variables at baseline ²

Length of stay

0.002 (0.001; 0.002)

<0.001

0.001 (0.001; 0.0011)

<0.001

Socio –demographic information

Age (years)

-0.02 (-0.06; 0.02)

0.312

-0.04 (-0.08; -0.004)

0.030

Women

-0.33 (-1.03; 0.38)

0.362

-0.51 (-1.13; 0.11)

0.108

Single

-0.80 (-1.58; -0.03)

0.042

-0.78 (-1.45; -0.11)

0.023

Ten years of education or less

0.46 (-0.25; 1.17)

0.206

0.45 (-0.14; 1.03)

0.136

Somatic health difficulties

Co-morbidity index

0.21 (-0.04; 0.46)

0.100

0.35 (0.15; 0.56)

0.001

No severe vision impairment

1.65 (0.77; 2.53)

<0.001

0.88 (0.14; 1.61)

0.019

No severe hearing impairment

-0.79 (-1.70; 0.13)

0.091

-0.16 (-0.92; 0.61)

0.689

Effect of additional variables assessed at 4 time-points ²

Degree of neuropsychiatric problems

Agitation sub-syndrome

0.04 (0.02; 0.06)

<0.001

0.03 (0.003; 0.05)

0.026

Psychosis sub- syndrome

0.02 (-0.01; 0.06)

0.173

Affective sub-syndrome

0.01 (-0.03; 0.04)

0.614

-0.03 (-0.06; 0.01)

0.166

Apathy

0.20 (0.15; 0.24)

<0.001

0.12 (0.08; 0.17)

<0.001

Use of psychotropic medication

Antipsychotics

0.77 (0.31; 1.23)

0.001

0.41 (-0.03; 0.86)

0.067

Antidepressants

-0.63 (-1.05; -0.20)

0.004

-0.40 (-0.80; 0.003)

0.052

Anxiolytics

-0.67 (-1.15; -0.20)

0.005

-0.77 (-1.22; -0.32)

0.001

Sedatives

-0.29 (-0.75; 0.17)

0.213

Cognitive enhancers

-2.31 (-2.94; -1.67)

<0.001

-1.72 (-2.33; -1.11)

<0.001