Figure 5
From: Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
Spirochetes in Alzheimer disease brain. (A) Detection in an immature senile plaque using a cocktail of specific antibodies against Borrelia burgdori (dark-brown staining). (B) Borrelia sequences in a mature plaque detected using in situ hybridization using a B. burgdorfi probe. (C) Detection in an amorphous plaque using an antibody to bacterial peptidoglycan. (D) Control brain stained with antibodies against B. Burgdorfi. Arrows in B indicate bodies resembling helical spirochetes. Scale bar, 80 μm for (A, D), 30 μm for (B), and 20 μm for (C). Figure kindly provided by Judith Miklossy, Switzerland.