Figure 4

Aβ in ATH plaque and in AD and senile cerebral amyloid angiopathy (CAA) macrophages and vessels. (A) ATH. Colocalization of iNOS-expressing macrophages with Aβ and platelets in advanced human atherosclerotic plaque. The panel shows double immunohistochemical stain for Aβ (red) and iNOS-positive macrophages (brown), showing close colocalization (arrows). Panel adapted, with permission, from [76]. (B) Aβ (red) in AD neurons and perivascular macrophages (green, anti-CD68 staining, a macrophage marker). Panel adapted, with permission, from [77](C) Aβ (red) in vessel walls in CAA (green staining: tissue transglutaminase, an extracellular matrix remodeling protein). Panel adapted, with permission, from [78].