Table 3 Diagnostic values in % (95% CI between brackets) for frailty for patients aged ≥ 70 years with and without cancer

aCGA

CUT-OFF ≥ 1

CUT-OFF ≥ 2

Sensitivity

85 (81 – 88)

79 (71 – 87)

87 (83 – 91)

58 (53 – 63)

Specificity

63 (58 – 68)

59 (50 – 68)

64 (59 – 70)

94 (91 – 96)

PPV

68 (64 – 73)

64 (55 – 73)

70 (65 – 75)

90 (87 – 93)

NPV

82 (78 – 85)

75 (67 – 83)

84 (80 – 88)

70 (66 – 75)

Classified as frail

60

59

61

31

VES-13

CUT-OFF ≥ 3

CUT-OFF ≥ 2

CUT-OFF ≥ 4

Sensitivity

78 (74 – 82)

67 (58 – 76)

82 (77 – 86)

81 (77 – 85)

74 (70 – 78)

Specificity

76 (72 – 80)

70 (61 – 78)

79 (74 – 83)

69 (65 – 74)

78 (74 – 82)

PPV

75 (71 – 80)

67 (58 – 76)

78 (73 – 83)

71 (67 – 76)

76 (72 – 80)

NPV

78 (74 – 82)

70 (61 – 78)

82 (77 – 86)

79 (75 – 83)

76 (72 – 80)

Classified as frail

50

48

51

55

47

GFI

CUT-OFF ≥ 4

CUT-OFF ≥ 3

CUT-OFF ≥ 5

Sensitivity

76 (71 – 86)

79 (61 – 87)

74 (69 – 79)

88 (84 – 91)

59 (54 – 63)

Specificity

73 (68 – 77)

71 (63 – 80)

73 (68 – 78)

49 (44 – 54)

83 (79 – 87)

PPV

72 (68 – 77)

72 (63 – 80)

72 (67 – 78)

62 (57 – 67)

76 (72 – 81)

NPV

76 (72–80)

78 (71 – 86)

75 (70 – 80)

81 (77 – 85)

68 (63 – 73)

Classified as frail

51

53

50

69

37

G8

CUT-OFF ≤ 14

CUT-OFF ≤ 13

CUT-OFF ≤ 15

Sensitivity

78 (74 – 82)

87 (80 – 93)

75 (70 – 80)

61 (56 – 65)

96 (94 – 98)

Specificity

68 (63 – 72)

64 (55 – 73)

69 (64 – 74)

86 (82 – 89)

39 (34 – 44)

PPV

70 (65 – 74)

69 (61 – 78)

70 (64 – 75)

80 (76 – 84)

60 (55 – 65)

NPV

77 (73 – 81)

84 (77 – 91)

75 (70 – 80)

70 (65 – 74)

91 (88 – 94)

Classified as frail

55

60

52

37

78