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Table 3 Accuracy of calcaneal QUS in predicting osteoporosis

From: Calcaneal quantitative ultrasound and Phalangeal radiographic absorptiometry alone or in combination in a triage approach for assessment of osteoporosis: a study of older women with a high prevalence of falls

Calcaneal QUS (n = 221) Youden1 UK-NOS triage approach 90% certainty level UK-NOS triage approach 95% certainty level
BUA upper/lower cutoff 93.88 105.88/86.63 114.5/80.09
Sensitivity (95% CI) 74.0 (64.3–82.3) 90.0 (82.7–95.1) 95.0 (88.7–98.4)
Specificity (95% CI) 78.5 (70.1–85.5) 90.1 (83.3–94.8) 95.0 (89.5–98.2)
PPV (95% CI) 74.0 (64.3–82.3) 80.6 (68.6–89.6) 83.3 (67.2–93.6)
NPV (95% CI) 78.5 (70.1–85.5) 85.7 (74.3–92.9) 88.1 (74.4–96)
False negative n (%) 26 (11.8) 10 (4.5) 5 (2.3)
False positive n (%) 26 (11.8) 12 (5.4) 6 (2.7)
DXA scans avoided n (%) NA 132 (59.7) 78 (35.3)
  1. Accuracy of calcaneal QUS in predicting osteoporosis applying the optimal cutoff and UK-NOS triage approach at 90% and 95% certainty levels. 1The optimal cutoff calculated according the Youden index [30]. Abbreviations: QUS Quantitative Ultrasound, BUA Broadband Ultrasound Attenuation, UK-NOS United Kingdom National Osteoporosis Society, PPV Positive Predictive Value, NPV Negative Predictive Value, DXA Dual Energy X-ray Absorptiometry, CI Confidence Interval, NA not available.