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Table 3 Handgrip strength (kg) in men ( n = 30) by success of short-term (“ONE MONTH”) and long-term (“SIX MONTHS”) withdrawal

From: Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics

ONE MONTH (short-term withdrawal)

Measurement point

 

Baseline

1 week

2 weeks

3 weeks

1 month

2 months

6 months

mean, SD

mean, SD

mean, SD

mean, SD

mean, SD

mean, SD

mean, SD

P 1

P 2

P 3

short-term withdrawers (n = 24)

42.9,

44.9*,

44.6*,

44.6*,

44.5*,

44.5*,

44.2*,

0.296

0.619

0.002

6.5

5.7

6.6

5.5

6.5

5.2

6.0

short-term non-withdrawers (n = 6)

40.3,

44.0*,

42.8*,

41.5*,

41.9*,

43.6*,

43.9*,

5.8

7.0

6.2

6.0

6.6

7.7

8.4

SIX MONTHS (long-term withdrawal)

Measurement point

 

Baseline

1 week

2 weeks

3 weeks

1 month

2 months

6 months

mean, SD

mean, SD

mean, SD

mean, SD

mean, SD

mean, SD

mean, SD

P 1

P 2

P 3

long-term withdrawers (n = 15)

41.5,

43.5§,

43.7§,

43.7§,

43.7§,

44.4§,

43.9§,

0.357

0.897

0.002

5.6

5.5

5.4

5.2

6.3

4.5

5.5

long-term non-withdrawers (n = 15)

43.3,

46.0§,

45.0§,

44.6§,

44.2§,

44.2§,

44.3§,

7.1

6.1

7.5

6.1

6.9

6.8

7.4

  1. P 1 = Statistical significance for group × time interaction effect; repeated measures analysis of variance.
  2. P 2 = Statistical significance for group effect; repeated measures analysis of variance; adjusted for time.
  3. P 3 = Statistical significance for time effect; repeated measures analysis of variance using Dunnett’s method in pairwise comparisons. After adjustment for group at one month’s time point handgrip strength was better* at 1 week (P = 0.002), at 2 weeks (P = 0.001), at 3 weeks (P = 0.001), at 1 month (P = 0.013), at 2 months (P = 0.001), and at 6 months (P = 0.006) compared to baseline. After adjustment for group at six months’ time point handgrip strength was better§ at 1 week (P = 0.002), at 2 weeks (P = 0.002), at 3 weeks (P = 0.001), at 1 month (P = 0.013), at 2 months (P = 0.001), and at 6 months (P = 0.006) compared to baseline.
  4. SD = Standard deviation.