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Table 6 Agreement beyond chance (Kappa coefficients) among different references regarding necessary drug changes when using the Cockroft-Gault equation for estimating eGFR

From: Kidney function and clinical recommendations of drug dose adjustment in geriatric patients

 

Dosing

AMP

BNF

DPRF

(95% CI)

(95% CI)

(95% CI)

(95% CI)

Renal Drug HB

0.15

0.10

0.23

0.20

(0.00-0.32)

(0.00-0.34)

(0.06-0.40)

(0.03-0.36)

Dosing

 

0.62

0.51

0.19

(0.47-0.78)

(0.35-0.68)

(0.02-0.35)

AMP

  

0.49

0.19

(0.34-0.65)

(0.05-0.34)

BNF

   

0.57

 

(0.40-0.73)

  1. 95% CI = 95% confidence interval;
  2. Renal Drug HB = The Renal Drug Handbook (19), Dosing = http://www.dosing.de (21), AMP = Arzneimittel Pocket (22), BNF = British National Formulary (20), DPRF = Drug Prescibing in Renal Failure (18).