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Table 5 Differences in the number of drugs that may require dose adjustment in kidney failure per patient according to the five literature sources

From: Kidney function and clinical recommendations of drug dose adjustment in geriatric patients

Nr. of Drugs

Renal Drug HB

Dosing

AMP

BNF

DPRF

0

7 (6%)

4 (13%)

9 (8%)

11 (10%)

7 (7%)

1

37 (34%)

19 (18%)

18 (17%)

23 (21%)

16 (15%)

2

33 (31%)

40 (37%)

28 (26%)

40 (37%)

34 (32%)

3

21 (19%)

25 (23%)

36 (33%)

25 (23%)

31(29%)

4

9 (8%)

7 (6%)

13 (12%)

7 (7%)

12 (11%)

5

1 (1%)

3 (3%)

3 (3%)

1 (1%)

5 (5%)

6

  

1 (1%)

0 (0%)

3 (3%)

7

   

1 (1%)

 

M (SD)

1.92 (1.10)

2.01 (1.20)

2.36 (1.26)

2.02 (1.20)

2.48 (1.34)

  1. Friedman-test for comparison of all literature sources: p < 0.001; Wilcoxon-test paired samples: p < 0.001 for Renal Drug HB vs. AMP, Dosing vs. AMP, Renal Drug HB vs. DPRF, Dosing vs.DPRF, AMP vs. BNF, BNF vs. DPRF, and p = 0.39 for Renal Drug HB vs. Dosing, p = 0.36 for RDB vs. BNF, p = 0.95 for Dosing vs. BNF, p = 0.22 for AMP vs. DPRF;
  2. M = Mean, SD = Standard deviation;
  3. Renal Drug HB = The Renal Drug Handbook (19), Dosing = http://www.dosing.de (21), AMP = Arzneimittel Pocket (22), BNF = British National Formulary (20), DPRF = Drug Prescibing in Renal Failure (18).