Model | SEM model including rs1042718and negative emotion | SEM model including rs1042719and negative emotion | ||||
---|---|---|---|---|---|---|
Independent variable | Coef. | Odds ratio | Independent variable | Coef. | Odds ratio | |
Depend. Variable: MMSE Score (Direct association) | rs1042718 carrier (no) | c =0.45* | 1.58* | rs1042719 carrier (no) | c =0.51** | 1.67** |
Age | −0.04 | 0.96 | Age | −0.04 | 0.96 | |
Male (female) | 0.42** | 1.52** | Male (female) | 0.47** | 1.59** | |
Urban (rural) | 0.06 | 1.06 | Urban (rural) | 0.07 | 1.07 | |
≥1 year of schooling (no) | 0.72*** | 2.06*** | ≥1 year of schooling (no) | 0.69*** | 2.00*** | |
Married (not-married) | 0.40 | 1.49 | Married (not-married) | 0.38 | 1.46 | |
Social/leisure activity ≥2 (<2) | 0.70*** | 2.01*** | Social/leisure activity ≥2 (<2) | 0.69*** | 2.00*** | |
Regular exercise (no) | 0.66*** | 1.93*** | Regular exercise (no) | 0.65*** | 1.92*** | |
Negative emotion (no) | b = -0.31 | 0.74 | Negative emotion (no) | b = -0.16 | 0.85 | |
Significant GxE interaction | ||||||
(rs1042718) x (Negative emotion) | −0.75** | 0.47** | (rs1042719)x(Negative emotion) | −0.77** | 0.46** | |
Depend. Variable: Negative emotion (controlling for the confounding effects) | rs1042718 carrier (no) | a = -0.34** | 0.71** | rs1042719 carrier (no) | a = -0.33* | 0.72* |
Age | 0.03 | 1.03 | Age | 0.02 | 1.02 | |
Male (female) | −0.33 | 0.72 | Male (female) | −0.28 | 0.76 | |
Urban (rural) | −0.13 | 0.88 | Urban (rural) | −0.13 | 0.88 | |
≥1 year of schooling (no) | 0.08 | 1.08 | ≥1 year of schooling (no) | 0.03 | 1.03 | |
Married (not-married) | 0.38 | 1.46 | Married (not-married) | 0.36 | 1.44 | |
Social/leisure activity ≥2 (<2) | −0.37** | 0.69** | Social/leisure activity ≥2 (<2) | −0.34* | 0.72* | |
Regular exercise (no) | −0.26 | 0.77 | Regular exercise (no) | −0.26 | 0.77 | |
Indirect association of ADRB2 with MMSE | Indirect association of carrying rs1042718 with MMSE through its rGE with negative emotion | a x b = (-0.34) x (-0.31) = 0.11 | 1.12 = exp(0.11) | Indirect association of carrying rs1042719 with MMSE through its rGE with negative emotion | a x b = (-0.33) x (-0.13) = 0.04 | 1.04 = exp(0.04) |