Table 5 Mean homocysteine, red cell folate and vitamin B12 concentration at baseline and follow up according to treatment group
Baseline: mean (standard deviation) | Follow-up: mean (standard deviation) | Difference (95% confidence interval) | P-value (paired t-test) | |
|---|---|---|---|---|
Homocysteine (micromol/L) | ||||
Placebo (n = 463) | 13.4 (5.0) | 14.3 (5.7) | 0.88 (0.40,1.36) | <0.001 |
B-Vitamins (n = 462) | 13.5 (6.3) | 10.5 (4.2) | −3.06 (−3.53,-2.59) | <0.001 |
Red cell Folate (nmol/L) | ||||
Placebo (n = 173) | 895.0 (466.6) | 1135.2 (666.8) | 244.8 (151.0,338.7) | <0.001 |
B-Vitamins (n = 183) | 959.2 (464.1) | 2181.5 (752.3) | 1220.0 (1117,1341) | <0.001 |
B 12 (pmol/L) | ||||
Placebo (n = 190) | 317.6 (140.8) | 315.3 (188.9) | −2.3 (−26.4,31.1) | 0.87 |
B-Vitamins (n – 196) | 322.1 (150.8) | 594.7 (271.9) | 272.6 (235.2,310.0) | <0.001 |