Association of biomarkers of inflammation and cell adhesion with lung function in the elderly: a population-based study

Table 2 Association between inflammatory markers and FEV ₁ or FVC when analysed by simple linear regression analysis

	FEV₁(% predicted)	p-value	FVC (% predicted)	p-value
Leukocyte count	−3.39 (−4.68, -2.11)	<0.0001	−2.44 (−3.63, -1.26)	<0.0001
CRP	−2.67 (−3.96, -1.38)	<0.0001	−1.51 (−2.70, -0.32)	0.01
EGF	1.42 (0.12, 2.71)	0.03	1.65 (0.47, 2.84)	0.006
VCAM-1	−1.17 (−2.46, 0.13)	0.08	−2.14 (−3.33, -0.96)	<0.0001
ICAM-1	−2.49 (−3.78, -1.20)	<0.0001	−1.16 (−2.35, 0.03)	0.06
E-selectin	−1.63 (−2.92, -0.33)	0.01	−1.84 (−3.03, -0.65)	0.002
MCP-1	0.44 (−0.86, 1.74)	0.50	0.51 (−0.69, 1.70)	0.41
IL-2	0.20 (−1.10, 1.50)	0.76	0.17 (−1.02, 1.37)	0.78
IL-6	−0.19 (−1.51, 1.12)	0.77	−1.01 (−2.22, 0.19)	0.10
IL-8	−0.47 (−1.78, 0.83)	0.48	−0.80 (−2.00, 0.39)	0.19
INF γ	0.13 (−1.18, 1.43)	0.85	−0.20 (−1.40, 0.99)	0.74
TNFα	0.01 (−1.29, 1.31)	0.99	−0.74 (−1.94, 0.45)	0.22
VEGF	−0.34 (−1.64, 0.96)	0.61	0.55 (−0.65, 1.74)	0.37
P-selectin	−0.75 (−2.05, 0.55)	0.26	−0.54 (−1.73, 0.66)	0.34
L-selectin	0.78 (−0.52, 2.08)	0.24	0.53 (−0.66, 1.73)	0.38

Values are β-coefficient (95% CI), in % per 1 SD change in biomarker. Markers that are significantly associated with lung function are presented in the first part of the table.

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