Table 1 Clinical characteristics of participants (mean ± SD and %)
Men (n=432) | Women (n=456) | All subjects (n=888) | |
|---|---|---|---|
BMI (kg/m2) | 27.1±3.6 | 27.0±4.8 | 27.0 ± 4.3 |
Current smokers | 10 | 11 | 10 |
Ex-smokers | 48 | 35 | 41 |
Never-smokers | 42 | 54 | 48 |
Hypertension | 31 | 32 | 32 |
Myocardial infarction | 10 | 3 | 7 |
Stroke | 4 | 2 | 3 |
FEV1 (L) | 2.88±0.62 | 2.02±0.41 | 2.44±0.68 |
FEV1 % predicted | 96±20 | 101±19 | 99±20 |
FVC (L) | 3.85±0.70 | 2.60±0.49 | 3.21±0.87 |
FVC % predicted | 95±16 | 108±18 | 102±18 |
Leukocyte count (x109/L) | 5.8±1.5 | 5.5±1.4 | 5.7±1.5 |
CRP (mg/L) | 1.2 (1.1-1.4) | 1.4 (1.3-1.5) | 1.3 (1.2-1.4) |
MCP-1 (ng/L) | 368 (355–381) | 366 (353–380) | 367 (358–377) |
IL-2 (ng/L) | 4.6 (4.2-4.9) | 5.0 (4.6-5.4) | 4.8 (4.5-5.0) |
IL-6 (ng/L) | 7.0 (6.0-8.1) | 5.8 (5.0-6.8) | 6.4 (5.7-7.1) |
IL-8 (ng/L) | 6.3 (5.9-6.7) | 6.6 (6.2-7.0) | 6.4 (6.2-6.7) |
INF γ (ng/L) | 1.8 (1.7-1.9) | 1.9 (1.8-2.0) | 1.8 (1.8-1.9) |
TNFα (ng/L) | 4.2 (4.0-4.4) | 4.0 (3.8-4.2) | 4.1 (3.9-4.2) |
EGF (ng/L) | 20.6 (18.7-22.8) | 24.2 (22.0-26.5) | 22.4 (20.9-23.9) |
VEGF (ng/L) | 161 (150–174) | 191 (177–206) | 176 (167–185) |
VCAM-1 (μg/L) | 540 (529–552) | 508 (497–520) | 524 (515–532) |
ICAM-1 (μg/L) | 346 (339–354) | 354 (345–362) | 350 (345–356) |
E-selectin (μg/L) | 15.0 (14.5-15.5) | 13.9 (13.3-14.4) | 14.4 (14.0-14.8) |
P-selectin (μg/L) | 99.2 (96.0-102) | 95.7 (93.2-98.3) | 97.4 (95.4-99.5) |
L-selectin (μg/L) | 688 (676–700) | 731 (718–744) | 709 (701–718) |