Table 6 Relationships between the baseline eGFR (at age 88 years), the eGFR slope (between age 85 and 88 years) and a combination of these two parameters and changes in the MMSE, GDS and ADL scores between age 88 and 90 years
All participants | eGFR slope per year between 85 and 88 years in ml/min/1.73 m²/year | P for the eGFR slope per year | ||||
|---|---|---|---|---|---|---|
>-1 | -1 to -2.99 | -3 to -4.99 | <-5 | |||
Mean change in the MMSE score (+SE) | ||||||
All participants (n=274) | -1.59 (0.22) | -1.30 (0.28) | -1.74 (0.40) | -2.39 (0.63) | -2.55 (1.49) | 0.33 |
eGFR 88 > 60 | -1.30 (0.30) | -1.09 (0.35) | -2.31 (0.75) | -2.00 (1.41) | -1.50 (1.5) | 0.27 |
eGFR 88: 45-60 | -1.55 (0.32) | -1.42 (0.45) | -1.14 (0.54) | -2.38 (0.99) | -3.14 (1.42) | 0.39 |
eGFR 88 < 45 | -2.66 (0.77) | -2.33 (1.71) | -2.62 (0.99) | -2.75 (1.22) | -4.50 (7.50) | 0.95 |
P (trend) for eGFR subgroups | 0.13 | 0.50 | 0.27 | 0.92 | 0.46 | |
Mean change in the GDS score (+SE) | ||||||
All participants (n=198) | 0.68 (0.20) | 0.82 (0.30) | 0.51 (0.24) | 0.70 (0.68) | -0.40 (1.12) | 0.76 |
eGFR 88 > 60 | 1.05 (0.36) | 1.09 (0.45) | 1.14 (0.64) | 1.00 (1.41) | -1.00 (3.00) | 0.86 |
eGFR 88: 45-60 | 0.50 (0.24) | 0.59 (0.43) | 0.37 (0.30) | 0.67 (0.56) | 0.00 (1.00) | 0.95 |
eGFR 88 < 45 | -0.5 (.59) | -0.50 (0.56) | 0.10 (0.43) | 0.33 (3.93) | / | 0.88 |
P (trend) for eGFR subgroups | 0.22 | 0.43 | 0.33 | 0.96 | 0.72 | |
Mean change in the ADL score (+SE) | ||||||
All participants (n=274) | 3.58 (0.35) | 3.88 (0.48) | 3.12 (0.64) | 3.42 (1.04) | 3.0 (1.17) | 0.79 |
eGFR 88 > 60 | 3.77 (0.56) | 4.04 (0.67) | 2.95 (1.35) | 2.86 (1.67) | 2.50 (2.50) | 0.86 |
eGFR 88: 45-60 | 3.05 (0.59) | 3.24 (0.68) | 2.57 (0.72) | 2.44 (1.62) | 3.43 (1.77) | 0.89 |
eGFR 88 < 45 | 5.05 (1.10) | 5.42 (2.18) | 4.75 (1.87) | 5.88 (1.89) | 2.00 (1.00) | 0.91 |
P (trend) for eGFR subgroups | 0.12 | 0.49 | 0.42 | 0.39 | 0.90 | |