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Table 5 Sensitivity analysis 2 for the relationships between both the eGFR at age 88 years and the decrease in the eGFR 3 years before (between age 85 and 88) and total and cardiovascular (CV) mortality

From: Prediction of mortality and functional decline by changes in eGFR in the very elderly: the Leiden 85-plus study

  

eGFR slope per year between 85 and 88 years in ml/min/1.73 m²/year

 

>-1

-1 to -2.99

-3 to -4.99

<-5

eGFR at age 88 > 60 (n=169)

 

n=128

n=26

n=12

n=3

Overall mortality

1 (ref)

1.44 (0.85-2.44)

2.77 (1.35-5.68)

4.41 (1.27-15.33)

CV mortality

1 (ref)

1.32 (0.48-3.67)

4.08 (1.39-11.96)

10.35 (2.46-43.61)

eGFR at age 88 45-59 (n=147)

 

n=71

n=46

n=21

n=9

Overall mortality

1 (ref)

0.89 (0.53-1.52)

1.58 (0.84-2.96)

3.37 (1.51-7.52)

CV mortality

1 (ref)

0.95 (0.38-2.37)

0.83 (0.22-3.09)

4.41 (1.24-15.78)

eGFR at age 88 < 45 (n=62)

 

n=20

n=21

n=14

n=7

Overall mortality

1 (ref)

0.74 (0.36-1.51)

0.50 (0.17-1.46)

2.26 (0.64-8.03)

CV mortality

1 (ref)

0.97 (0.37-2.54)

0.29 (0.04-2.32)

4.04 (1.01-16.20)

  1. The results are presented as the HR (95% CI) and were adjusted for the change in weight between 85 and 88 years, history of MI and gender. The results are shown with one reference group for each eGFR subgroup.
  2. * No events.