Table 1 Demographics and baseline characteristics of the intent-to-treat population
Characteristic | Donepezil 23 mg/d | Donepezil 10 mg/d |
|---|---|---|
Age, years | ||
Number of patients | 909 | 462 |
Mean (± SD) | 73.8 (8.48) | 73.8 (8.55) |
Median | 75.0 | 75.0 |
Range | 47-89 | 49-90 |
Gender | ||
Number of patients | 909 | 462 |
Males, n (%) | 335 (36.9) | 175 (37.9) |
Females, n (%) | 574 (63.1) | 287 (62.1) |
Weight, kg | ||
Number of patients | 908 | 462 |
Mean (± SD) | 66.7 (14.8) | 66.2 (14.4) |
Median | 65.5 | 64.5 |
MMSE | ||
Number of patients | 908 | 462 |
Mean (± SD) | 13.1 (4.99) | 13.1 (4.72) |
Median | 14.0 | 14.0 |
ADCS-ADL-sev | ||
Number of patients | 908 | 461 |
Mean (± SD) | 34.1 (10.88) | 34.5 (11.19) |
Median | 36.0 | 36.0 |
SIB | ||
Number of patients | 907 | 462 |
Mean (± SD) | 74.2 (17.58) | 75.6 (16.28) |
Median | 81.0 | 82.0 |
CIBIS-plus | ||
Number of patients | 904 | 461 |
Mean (± SD) | 4.42 (0.85) | 4.38 (0.89) |
Median | 4.0 | 4.0 |
Duration of prestudy | ||
donepezil 10 mg/d, weeks | ||
Number of patients | 909 | 462 |
Mean (±SD) | 113.4 (108.4) | 104.9 (99.2) |
Median | 71.9 | 66.3 |