Any laxative use | N | HR (95% CI)** |
|---|
| | | Falls (>2) | Hip fracture | Total fracture |
|---|
Nonuser | 151,497 | 1 | 1 | 1 |
< 1 year | 1924 | 1.11 (1.04, 1.74) | 1.17 (0.89, 1.55) | 1.06 (0.97, 1.16) |
1-3 years | 3091 | 1.07 (0.99, 1.15) | 1.02 (0.69, 1.50) | 1.03 (0.92, 1.15) |
> 3 years | 3892 | 1.00 (0.95, 1.06) | 0.90 (0.68, 1.19) | 0.97 (0.89, 1.05) |
p-value for linear trend | | 0.0458 | 0.9553 | 0.9996 |
- ** Adjusted for age, ethnicity, BMI, WHI clinical trial indicators, smoking status, physical activity, self-reported health, treated diabetes, history of fracture after age 55, corticosteroid use, physical function score, number of chronic medical conditions (including treated diabetes mellitus, stroke, any cancer, CVD, arthritis, hypertension, 2 or more falls and emphysema), number of psychoactive drugs (including antipsychotic, antiepileptic, anxiolytic, hypnotic and antidepressant drug use), use of HRT, and bisphosphonate use.
