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Table 2 Relative gene expression in aging skeletal muscle

From: Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia

 

Age (months)

 

6 ( n = 16)

12 ( n = 18)

18 ( n = 12)

24 ( n = 12)

Gene expression (AU)

    

  NOX2

13.1 ± 2.9

11.0 ± 3.1

110 ± 14.7abd

23.0 ± 4.4

  p22phox

17.8 ± 3.7

26.5 ±7.0

25.1 ± 9.4

48.7 ± 10.3

  p40phox

14.0 ± 4.9

25.2 ± 8.7

57.7 ± 16.9a

42.9 ± 8.9

  p47phox

3.1 ± 0.6

4.8 ± 1.4

16.4 ± 7.9

4.2 ± 1.2

  p67phox

72.9 ± 13.4

41.1 ± 8.9

103 ± 33.0

272 ± 71abc

  NOX4

1.5 ± 0.3

4.3 ± 1.0

9.2 ± 3.2a

5.1 ± 1.3

  Rac1

1.2 ± 1.1

3.91 ± 0.9

2.9 ± 1.3

5.3 ± 0.8

  SOD1

16.1 ± 5.2

19.3 ± 5.1

33.6 ± 11.0

69.6 ± 15.6abc

  SOD2

7.9 ± 2.1

6.6 ± 1.5

6.7 ± 2.6

19.5 ± 4.0abc

  SOD3

1.7 ± 0.4

1.51 ± 0.2

2.5 ± 1.3

2.9 ± 0.8

  Gpx

16.5 ± 4.3

42.2 ± 10.2

56.4 ± 22.7

40.5 ± 6.0a

  Catalase

19.4 ± 5.1

28.1 ± 8.1

34.4 ± 10.3

52.0 ± 9.0

  1. The values represent the mean ± SEM, with all results normalised to 18 s ribosomal mRNA. Statistically significant differences (P < 0.05) between groups are indicated by lower case letters, where a6 m/o, b12 m/o, c18 m/o and d24 m/o.