Use of CNS medications and cognitive decline in the aged: a longitudinal population-based study

BMC Geriatrics

Table 2 Use of combinations of CNS medications

Combinations of medications	Sex						Age
	Both		Men		Women		65-74		75+
	(N = 565)		(N = 227)		(N = 338)		(N = 439)		(N = 126)
	N	%	N	%	N	%	N	%	N	%
Opioid and
anticholinergic	1	0.2	0	0	1	0.3	1	0.2	0	0
antiepileptic	0	0	0	0	0	0	0	0	0	0
benzodiazepine or related drug	4	0.7	0	0	4	1.2	1	0.2	3	2.4
antipsychotic	2	0.4	0	0	2	0.6	2	0.5	0	0
antidepressant	1	0.2	0	0	1	0.3	1	0.2	0	0
any of the above drugs	6	1.1	0	0	6	1.8	3	0.7	3	2.3
Anticholinergic and
antiepileptic	1	0.2	1	0.4	0	0	0	0	1	0.8
benzodiazepine or related drug	32	5.7	11	4.8	21	6.2	19	4.3	13	10.3
antipsychotic	22	3.9	6	2.6	16	4.7	13	3.0	9	7.1
antidepressant	9	1.6	3	1.3	6	1.8	8	1.8	1	0.8
any of the above drugs	48	8.5	15	6.6	33	9.8	31	7.1	17	13.5
Antiepileptic and
antidepressant	0	0	0	0	0	0	0	0	0	0
benzodiazepine or related drug	3	0.5	3	1.3	0	0	2	4.6	1	0.8
antipsychotic	1	0.2	1	0.4	0	0	0	0	1	0.8
any of the above drugs	3	0.5	3	1.3	0	0	2	0.5	1	0.8
Benzodiazepine or related drug and
antipsychotic	13	2.3	5	2.2	8	2.4	7	1.6	6	4.8
antidepressant	12	2.1	2	0.9	10	3.0	9	2.1	3	2.4
any of the above drugs	46	8.1	14	6.2	32	9.5	28	6.4	18	14.3
Antipsychotic and
antidepressant	5	0.9	1	0.4	4	1.2	3	0.7	2	1.6
any of the above drugs	28	5.0	7	3.1	21	6.2	17	3.9	11	8.7
Antidepressant and
any of the above drugs	19	3.4	4	1.8	15	4.4	15	3.4	4	3.2

Number and proportion of participants using a combination of CNS medications at baseline, by sex and age.
CNS = central nervous system

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