From: Sedative load of medications prescribed for older people with dementia in care homes
Parameter | Care home at each time point | Â | Â | p - Value | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | 1 |  |  | 2 |  |  | 3 |  |  | 4 |  |  | 5 |  |  | 6 |  |  |  |  |  |
 | BL | TP2 | TP3 | BL | TP2 | TP3 | BL | TP2 | TP3 | BL | TP2 | TP3 | BL | TP2 | TP3 | BL | TP2 | TP3 | BL | TP2 | TP3 |
Number of residents (n) | 20 | 20 | 19 | 17 | 17 | 16 | 14 | 14 | 14 | 22 | 22 | 21 | 30 | 27 | 25 | 12 | 12 | 10 | Â | Â | Â |
Number of regular medications | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Mean | 6.70 | 5.10 | 5.11 | 7.41 | 5.88 | 6.00 | 5.79 | 5.57 | 5.57 | 4.36 | 4.41 | 4.33 | 6.17 | 6.74 | 6.88 | 5.17 | 5.75 | 5.90 | 0.07 | 0.13 | 0.10 |
Range | 1-10 | 1-8 | 1-8 | 2-18 | 2-11 | 2-11 | 1-10 | 0-13 | 0-13 | 0-8 | 0-9 | 1-9 | 0-10 | 0-13 | 0-13 | 0-12 | 0-12 | 1-12 | Â | Â | Â |
Standard deviation | 3.18 | 2.40 | 2.47 | 4.83 | 3.06 | 3.12 | 3.17 | 3.28 | 3.28 | 2.11 | 2.32 | 2.35 | 2.51 | 3.58 | 3.59 | 3.86 | 3.14 | 3.51 | Â | Â | Â |
Polypharmacy (>4 medications) [no.(%)] | 16 (80.0) | 18 (90.0) | 14 (73.6) | 15 (88.2) | 14 (82.3) | 12 (75.0) | 9 (64.2) | 5 (35.7) | 10 (74.1) | 14 (63.6) | 16 (72.7) | 11 (52.4) | 25 (83.3) | 20 (74.0) | 23 (92.0) | 7 (58.3) | 5 (41.7) | 9 (90.0) | 0.02 | 0.19 | 0.08 |
Sedative Load | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Mean | 1.05 | 1.35 | 1.47 | 1.29 | 1.06 | 0.75 | 1.21 | 1.36 | 1.36 | 1.32 | 1.50 | 1.38 | 1.03 | 1.07 | 1.32 | 1.08 | 1.42 | 1.30 | 0.84 | 0.59 | 0.39 |
Range | 0-5 | 0-5 | 0-5 | 0-6 | 0-3 | 0-3 | 0-4 | 0-4 | 0-5 | 0-3 | 0-3 | 0-3 | 0-3 | 0-4 | 0-4 | 0-3 | 0-3 | 0-2 | Â | Â | Â |
Standard deviation | 1.32 | 1.35 | 1.31 | 1.40 | 0.83 | 0.86 | 1.31 | 1.45 | 1.69 | 0.99 | 0.96 | 0.97 | 0.98 | 1.11 | 1.22 | 1.12 | 0.9 | 0.68 | Â | Â | Â |
Antipsychotics [no.(%)] | 2 (10.0) | 4 (20.0) | 5 (26.3) | 7 (41.2) | 6 (35.3) | 4 (25.0) | 2 (14.3) | 1 (7.1) | 1 (7.1) | 7 (32.0) | 6 (27.3) | 5 (23.8) | 3 (10.0) | 3 (11.1) | 4 (16.0) | 2 (16.8) | 1 (8.3) | 0 | 0.02 | 0.17 | 0.04 |
Antidepressants [no.(%)] | 11 (55.0) | 12 (60.0) | 11 (57.9) | 9 (52.9) | 6 (35.3) | 4 (25.0) | 5 (35.7) | 8 (57.1) | 9 (64.3) | 15 (68.2) | 14 (63.6) | 13 (61.9) | 10 (33.3) | 11 (40.7) | 11 (44.0) | 4 (33.3) | 6 (50.0) | 6 (60.0) | 0.29 | 0.41 | 0.35 |
Hypnotics and anxiolytics [no.(%)] | 1 (5.0) | 1 (5.0) | 1 (5.3) | 1 (5.9) | 0 | 0 | 3 (21.4) | 3 (21.4) | 2 (14.3) | 2 (9.1) | 2 (9.1) | 2 (9.5) | 4 (13.3) | 5 (18.5) | 5 (20.0) | 2 (16.7) | 3 (25.0) | 2 (20.0) | 0.06 | 0.14 | 0.23 |