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Table 3 Effect size and study power analysis of memory performance measures, global cognitive function and mood, in trials of cognitive exercises in mild cognitive impairment (MCI)

From: Cognitive and memory training in adults at risk of dementia: A Systematic Review

Citation

Design

Outcome measure

Effect size and 95% confidence Interval

ES > .5 or < -.5

Power of study

> 1 whole number change in test score

Could Type II errors explain lack of significance?

Gunther et al 2003

UCT

Repeat sentence T1

.46 (-.18, 1.11)

No

Single

Yes

Yes

  

Repeat sentences T2

.17 (-.50, .83)

No

group

Yes

 
  

CVLT list immediate T1

.80 (.14, 1.47)

Yes

 

Yes

 
  

CVLT list immediate T2

.35 (-3.2, 1.02)

No

 

Yes

 
  

CVLT Word lists delay T1

1.21 (-.52, 1.91)

Yes

 

Yes

 
  

CVLT Wordlist delay T2

.45 (-.22, 1.12)

No

 

Yes

 

Olazaran et al 2004

RCT

ADAS-Cog

.84 (-.53, 2.21)

Yes

.30

No

Yes

  

MMSE

-.10 (-1.43, 1.23)

No

.06

No

 
  

GDS^

-.33 (-1.23, 1.17)

No

.05

No

 

Cipriani et al 2006

UCT

MMSE

.50 (-.39, 1.39)

Yes

Single

No

Yes

  

RBMT

.64 (-.26, 1.54)

Yes

group

Yes

 
  

GDS^

-.33 (-1.21,.55)

No

 

Yes

 

Rozzini et al 2007

RCT

Story recall vs C1

.99 (.29, 1.68)

Yes

.52

Yes

Yes

  

Story recall vs C2

.82 (.14, 1.50)

Yes

.77

Yes

 
  

MMSE vs C1

-.37 (-1.04, .29)

No

.19

No

 
  

MMSE vs C2

-.58 (-1.25, .09)

Yes

.52

No

 
  

NPI^ vs C1

-.82 (-1.5, -.14)

Yes

.77

Yes

 
  

NPI^ vs C2

-.64 (-1.31, -.14)

Yes

.92

Yes

 
  

GDS^ vs C1

-.26 (-.92, 1.29)

No

.45

No

 
  

GDS^ vs C2

-.52 (-1.18, 15)

Yes

.54

No

 

Talassi et al 2007

NRCT

MMSE

.07(-.76, .89)

No

.14

No

No

  

Episodic immediate

.10(-.73, .92)

No

.12

No

 
  

Episodic delay

.14 (-.96, .68)

No

.09

No

 
  

GDS^

-.35(-1.18, .47)

No

.20

Yes

 

Barnes et al 2009

RCT

RBANS total

0.33 (-.26, -0.92)

No

.29

 

Yes

  

RBANS immediate memory

.38 (-.21,-0.96)

No

.35

  
  

RBANS delay memory

.53 (-.05, -1.10)

Yes

.55

  
  

GDS^

No data

    
  1. ES: Effect size. Relative ES for RCTs and NRCT, and ES for single intervention group in UCT were calculated by authors of this review as described in the methods analysis
  2. Power analysis calculated by the authors of this review as described in the methods analysis. *Significance of effect size contrast from authors' ES analysis
  3. NRCT: Non-randomised controlled trial
  4. UCT: Uncontrolled trial
  5. T1: Immediate
  6. T2: At follow-up
  7. C1: Control Cholinesterase inhibitor
  8. C2: Control
  9. ADAS-Cog: Alzheimer Disease Assessment Scale-Cognitive
  10. NPI: Neuropsychiatry Inventory
  11. MMSE: Mini Mental Status Examination