From: Cognitive and memory training in adults at risk of dementia: A Systematic Review
Citation | Study Design | Type of Training | MCI Sample size (n) | Age (yrs) | Gender (% male) | MMSE (0-30) | Criteria for diagnosis of MCI | Exclusion of co-morbidities |
---|---|---|---|---|---|---|---|---|
Rapp et al 2002 | RCT | Memory strategies | Total n = 19 | Â | Â | Â | Petersen (1999) | not reported |
 |  |  | Treatment n = 9 | 73.3 (6.6) | 11% | 28 (1.5) |  |  |
 |  |  | Control n = 10 | 75.1 (7.03) | 70% | 27.3 (1.8) |  |  |
Gunther et al 2003 | UCT | Cognitive exercise | n = 19 | 75-91 | 21 | not reported | Age Associated Memory Impairment, no Dementia, subjective & objective memory complaint, | not reported |
Olazaran et al 2004 | RCT | Cognitive exercise | Total n = 12 | Â | 35%* | Â | Flicker (1991) | Physical condition precluding full participation. Illiteracy. |
 |  |  | Treatment n = 8 | 75.3 (1.05)* |  | 17.2 (3.6) | Neuro-imaging studies |  |
 |  |  | Control n = 4 | 73.3 (1.05)* |  | 21.7 (5.9) |  |  |
Belleville et al 2006 | NRCT | Memory strategies | Total n = 28 | Â | Â | Â | Petersen (2001) | Alzheimer's Disease, alcoholism or "toxicomania", presence of history of psychiatric or neurological disorder, general anaesthesia in the last 6 months |
 |  |  | Treatment n = 20 | 62.3 (7.3) | not reported | 28.9 (1.2) |  |  |
 |  |  | Control = 8 | not reported | not reported | not reported |  |  |
Cipriani et al 2006 | UCT | Cognitive exercise | n = 10 | 70.6 (6.0) | not reported | 28.0 (1.4) | not reported | not reported |
Rozzini et al 2007 | RCT | Cognitive exercise | Total n = 59 | 63-7 ** | not reported | Â | Petersen (2001) | Geriatric Depression Scale (GDS) > 5 |
 |  |  | Treatment CT & ChEI n = 15 |  |  | 26.0 (1.6) | Neuro-imaging studies | Probable or possible Alzheimer Disease, Drug or alcohol abuse or dependence according to DSM-IV criteria, poorly controlled diabetes or other medical condition incompatible with treatment, Previous treatment with ChEIs, Intake of antidepressants during the period of study. |
 |  |  | Control I ChEI n = 22 |  |  | 26.4 (1.9) |  |  |
 |  |  | Control II n = 22 |  |  | 26.8 (1.8) |  |  |
Talassi et al 2007 | NRCT | Cognitive exercise | Total n = 37 | Â | Â | Â | Petersen (1997) | not reported |
 |  |  | Treatment n = 30 | 76.2 (7.3) | not reported | 27.5 (1.4) |  |  |
 |  |  | Control n = 7 | 76.1 (7.0) | not reported | 26.9(1.9) |  |  |
Wenisch et al 2007 | NRCT | Memory strategies | Total = 24 | 73.0 (5.5) | 33.3 | 28.1 (.9) | Petersen (2001) | Illiteracy, physical condition preventing full participation, prior cognitive stimulation therapy |
 |  |  | Treatment n = 12 |  |  |  |  |  |
 |  |  | Control n = 12 Healthy |  |  |  |  |  |
Troyer et al 2008 | RCT | Memory strategies | Total n = 50 | Â | Â | Â | Petersen (2004) | not reported |
 |  |  | Treatment n = 24 | 76.0 (5.6) | 45% | 27.2(1.9) |  |  |
 |  |  | Control n = 26 | 74.8 (7.7) | 45% | 28.5(1.0) |  |  |
Barnes et al 2009 | RCT | Cognitive exercise | Total n = 47 | Â | Â | Â | Winbald (2004) | Cerebrovascular disease, starting treatment with ChEIs |
 |  |  | Treatment n = 22 | 74.1 (8.7) | 59.1% | not reported |  |  |
 |  |  | Control n = 25 | 74.8 (7.2) | 60% | not reported |  |  |