From: Hypothermia predicts mortality in critically ill elderly patients with sepsis
Variable | Died in hospital Mean (SD) (n = 38) | Survived to hospital discharge Mean (SD) (n = 70) | P Value |
---|---|---|---|
Median age (IQR) | 75 (70-78.2) | 76 (71-80.5) | 0.63 |
Sex (M:F) | 19:19 | 45:23 | 0.14** |
Co-morbidities | |||
Chronic renal failure (%) | 14.7 | 14.5 | 1.00** |
Chronic obstructive pulmonary disease (%) | 38.2 | 21.8 | 0.14** |
Congestive cardiac failure/Ischemic heart disease/Hypertension (%) | 67.6 | 77.1 | 0.33** |
Diabetes mellitus (%) | 18.7 | 24.5 | 0.60** |
Physiological variables | Median (IQR) | Median (IQR) | |
PaO2 (torr) | 113 (73.5 -195) | 99. (75-167) | 0.31 |
PaCO2 (torr) | 39 (31.5-57) | 39 (33-45) | 0.21 |
HCO3(mmol/L)* | 15.41 (6.45) | 19.56 (4.02) | < 0.01 |
pH | 7.15 (6.99-7.31) | 7.31 (7.23-7.38) | < 0.01 |
Heart rate | 110 (90-127.5) | 105 (86-114) | 0.11 |
Systolic blood pressure (mmHg) | 132 (105-147) | 140 (120-154) | 0.12 |
Diastolic blood pressure(mmHg) | 60 (50-68) | 65 (50-75.2) | 0.10 |
Mean blood pressure(mmHg) | 82 (72-92.5) | 89.5 (80.7-99) | 0.04 |
Temperature (degree Celsius) | 36.7 (35.4-37.9) | 37.3 (36.8-37.9) | 0.06 |
Respiratory rate | 24 (15.5-32) | 26 (21.7-30) | 0.60 |
Number of organs failed | 2 (1-3) | 1 (0-1) | < 0.01 |
Laboratory variables | |||
Sodium (mmol/L) | 143 (140-145) | 141 (138-144) | 0.14 |
Potassium (mmol/L) | 4.78 (0.92) | 4.33 (0.64) | 0.01 |
Urea (mmol/L) | 16.4 (9.7-23.9) | 12.6 (8.1-19.7) | 0.16 |
Creatinine (umol/L) | 185 (130-250) | 130 (90-241) | 0.05 |
Bilirubin (umol/L) | 18 (9-35) | 14 (8-26) | 0.47 |
Albumin (g/L) | 27.29 (7.49) | 30.25 (4.60) | 0.04 |
Blood sugar (mmol/L) | 9.3 (6.7-14.3) | 9.6 (6.5-11.5) | 0.55 |
C reactive protein (mg/L) | 163 (78.5-248.1) | 168.7 (61-254.1) | 0.87 |
Lactate (mmol/L) | 4 (2-10.1) | 2.2 (1.3-4.0) | < 0.01 |
White cell count (×10^9/L) | 14.5 (7.2-23) | 15.4 (11.3-24) | 0.21 |
Hematocrit (%) | 0.31 (0.27-0.36) | 0.32 (0.27-35) | 0.90 |
Positive culture in the first 24 hours (%) | 51.4 | 38.5 | 0.28** |
Scores | |||
APACHE III | 91 (76.5-114.5) | 65 (53.7 -83) | < 0.01 |
SAPS II | 57 (45.5-70) | 43.5 (37-50) | < 0.01 |
Outcome | |||
Duration of ICU stay (days; Mean (SD)) | 2 (1-6.2) | 2 (1-6) | 0.97 |
Duration of hospital stay (days; Mean (SD)) | 9 (3-32) | 15 (8-31.5) | 0.09 |