Figure 1

Hazard ratios. Cox PH models were used to calculate the hazard ratio associated with each of the 377 predictor variables. In each plot, vertical lines represent 95% confidence intervals associated with log-transformed hazard ratios, with red lines indicating statistical significance of estimated ratios (P < 0.05). Lines representing confidence intervals are ordered with respect to a variable ranking based upon the hazard ratio point estimate obtained for each variable. In part (A), hazard ratios for each predictor variable were estimated using a univariate model without other covariate terms. In parts (B) - (F), hazard ratios were adjusted for one or more covariates. These covariates include (B) baseline age, (C) age and smoking history, (D) age, smoking and diabetes history, (E) age, smoking history, diabetes history and hypertension, and (F) age, smoking history, diabetes history, hypertension and self-rated health.