Thiazides in the management of hypertension in older adults – a systematic review

BMC Geriatrics

Table 2 Results of quality appraisal of the interventional studies according to the Cochrane Handbook of Interventions

Source	Type of study	Selection bias		Performance bias	Detection bias	Attrition bias	Reporting bias
Source	Type of study	1. Random sequence generation	2. Allocation concealment	3. Blinding of participants and personnel	4. Blinding of outcome assessment	5. Incomplete outcome data	6. Selective reporting	7. Other bias
ACCOMPLISH Jamerson et al. 2008 [40]	Multicentre trial in US and North Europe	UR	LR	LR	LR	LR	UR	UR
ALLHAT 2002 [24]	double blind RCT	LR	LR	LR	LR	LR	LR	UR
Chalmers et al. 2000 [28]	double blind RCT	UR	UR	LR	LR	LR	LR	UR
EWPHE Amery et al. 1985 [31], Fletcher 1991 [32], Staessen et al. 1989 [33] Staessen et al. 1991 [34]	double blind RCT	LR	UR	LR	LR	HR	LR	UR
HSCS 1974 [36]	double blind RCT	UR	UR	LR	UR	UR	LR	HR
HYVET pilot Bulpitt et al. 2003 [39]	RCT	LR	LR	HR	HR	LR	LR	LR
HYVET Beckett et al. 2008 [37]	double-blind RCT	LR	LR	LR	LR	UR	LR	LR
Kuramoto et al. 1981 [41]	Prospective clinical trial	UR	UR	UR	UR	HR	LR	HR
MRC-O trial 1992 [44]	single blind RCT	UR	UR	LR	LR	HR	UR	HR
SHELL Malacco et al. 2003 [44]	RCT open design	LR	UR	HR	HR	HR	LR	HR
SHEP pilot Hulley et al. 1985 [46] Perry et al. 1986 [47] Perry et al. 1989 [48]	double-blind RCT	LR	UR	LR	LR	HR	UR	UR
SHEP SHEP Group 1991 [49], Hawkins 1993 [50], Perry et al. 2000 [51], Kostis et al. 1997 [52], Curb et al. 1996 [53], Savage et al. 1998 [58], Somes et al. 1999 [55]	double-blind RCT	LR	LR	LR	LR	LR	LR	UR

LR low risk of bias, HR high risk of bias, RCT Randomized controlled trial, UR unclear risk of bias

ISSN: 1471-2318