The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial

Table 1 SPIRIT diagram outlining schedule of enrolment, interventions, and assessments for study participants

Timepoints		Pre-screening telephone call	Baseline assessment T0	Study assessment T1	Study assessment T2
			<13 days following screening	6 months after study visit 1	12 months after study visit 1
Enrolment	Explain study	X
Enrolment	Screen eligibility criteria	X
Study Outcomes	Neuropsychological testing		X	X	X
	MoCA		X	X	X
	DemQOL		X	X	X
	CES-D		X	X	X
	Incremental Exercise Test		X	X	X
	Physical Activity Tracker		X	X	X
	LAPAQ		X	X	X
	Blood sampling		X		X
	NEO-FFI		X		X
	MRI Brain^a		X		X
	TUG		X	X	X
	Hand Grip Strength		X	X	X
	30 second chair stand		X	X	X
	Randomisation (after completion of all baseline assessments)		X
	Exercise intervention^b		X	X	X

^aMRI brain will be performed in Cologne and Nijmegen sites
^bAfter completion of T0 assessment, participants will be randomised to one of the three groups (aerobic exercise, stretching and toning exercise, control group). Exercise intervention will be continuous for a 12-month duration following completion of T0 assessments

ISSN: 1471-2318