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Table 3 Validity of Mindstreams tests in discriminating mild cognitive impairment (MCI; N = 20) from cognitively healthy elderly (N = 15) as compared with traditional paper-based tests of the same cognitive domains.

From: Validity of a novel computerized cognitive battery for mild cognitive impairment

Cognitive Domain

Mindstreams Test (outcome parameter)

AUC

SE

Asymptotic Significance

95% CI

Traditional Measure

AUC

SE

Asymptotic Significance

95% CI

MEMORY

Verbal Memory (accuracy, first repetition trial)

0.848

0.066

0.001

0.719–0.977

WMS-III Logical Memory I

0.800

0.076

0.003

0.650–0.950

 

Verbal Memory (accuracy, second repetition trial)

0.831

0.071

0.001

0.692–0.971

WMS-III Logical Memory II

0.885

0.055

0.000

0.778–0.992

 

Verbal Memory (accuracy, third repetition trial)

0.720

0.089

0.031

0.547–0.894

RAVLT Immediate Recall A

0.632

0.096

0.188

0.443–0.820

 

Verbal Memory Accuracy (accuracy, final repetition trial)

0.752

0.086

0.014

0.583–0.920

RAVLT Total

0.833

0.068

0.001

0.701–0.966

 

Verbal Memory (accuracy, all repetition trials)

0.894

0.056

0.000

0.785–1.000

RAVLT Immediate Recall B

0.688

0.091

0.06

0.510–0.866

 

Verbal Memory (accuracy, delayed recognition)

0.748

0.085

0.015

0.582–0.914

RAVLT Short Term Retention

0.874

0.062

0.000

0.752–0.995

 

Non-Verbal Memory (accuracy, first repetition trial)

0.654

0.097

0.127

0.464–0.844

RAVLT Delayed Recall

0.846

0.073

0.001

0.702–0.990

 

Non-Verbal Memory (accuracy, second repetition trial)

0.681

0.095

0.074

0.494–0.867

RAVLT Recognition

0.823

0.073

0.001

0.680–0.965

 

Non-Verbal Memory (accuracy, third repetition trial)

0.642

0.097

0.160

0.453–0.831

     
 

Non-Verbal Memory Accuracy (accuracy, final repetition trial)

0.686

0.093

0.066

0.505–0.867

     
 

Non-Verbal Memory (accuracy, all repetition trials)

0.719

0.090

0.030

0.542–0.897

     
 

Non-Verbal Memory (accuracy, delayed recognition)

0.684

0.094

0.069

0.499–0.869

     

EXECUTIVE FUNCTION

Go-NoGo (accuracy)

0.742

0.088

0.019

0.570–0.915

Clock Drawing

0.680

0.092

0.072

0.499–0.861

 

Go-NoGo (performance index)

0.840

0.069

0.001

0.705–0.976

Trail Making Test A

0.660

0.092

0.11

0.479–0.841

 

Problem Solving (accuracy)

0.685

0.098

0.077

0.492–0.877

WAIS-III Digit Symbol

0.729

0.091

0.03

0.550–0.908

      

WMS-III Mental Control

0.706

0.092

0.05

0.525–0.888

VISUAL SPATIAL

Visual Spatial Imagery (accuracy)

0.778

0.079

0.007

0.622–0.934

WAIS-III Block Design

0.599

0.102

0.347

0.400–0.798

VERBAL

Verbal Function (accuracy, naming)

0.777

0.085

0.009

0.610–0.944

Boston Naming Test

0.747

0.082

0.014

0.585–0.908

 

Verbal Function (accuracy, rhyming)

0.837

0.070

0.001

0.700–0.973

COWA FS

0.768

0.081

0.008

0.609–0.928

      

COWA A

0.739

0.086

0.018

0.570–0.907

      

COWA Animals

0.711

0.088

0.037

0.538–0.883

      

WAIS-III Similarities

0.553

0.11

0.618

0.337–0.768

  1. Mindstreams outcome parameters with insufficient data (<13 data points per group) due to failed practice sessions (see Methods) were excluded. AUC = area under the curve WMS-III = Wechsler Memory Scale, 3rd edition SE = standard error RAVLT = Rey Auditory Verbal Learning Test, Version 1 CI = confidence interval WAIS-III = Wechsler Adult Intelligence Scale, 3rd Edition RT = reaction time COWA = Controlled Oral Word Association
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BMC Geriatrics

ISSN: 1471-2318

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