Harm avoidance is associated with progression of parkinsonism in community-dwelling older adults: a prospective cohort study

Table 3 Association of harm avoidance subscores in a typical participant with the level and the annual rate of change in parkinsonism, adjusted for demographic variables*

Harm avoidance subscore	Annual rate of change in parkinsonism	Subscore & level of parkinsonism	Subscore X annual rate of change in parkinsonism
Anticipatory worry	0.056 (0.007, <0.001)	0.039 (0.016, 0.017)	0.009 (0.003,0.005)
Fear of uncertainty	0.058 (0.008, <0.001)	0.035 (0.021, 0.163)	0.008 (0.004,0.034)
Shyness	0.054 (0.008, <0.001)	-0.100 (0.016, 0.51)	0.008 (0.003,0.007)
Fatigability	0.061 (0.008, <0.001)	0.119 (0.014, <0.001)	0.010 (0.003,<0.001)

*We repeated the model shown in Table 2, four times replacing harm avoidance with each of its 4 subscores. Each row shows the results for a separate linear mixed effect models for a different subscore. The first term is the annual rate of change in parkinsonism; the 2^nd term is the relationship between the subscore and level of parkinsonism and the 3^rd columns shows the relationship between the subscore and the annual rate of change in parkinsonism. Each model also included terms (not shown) which controlled for age, sex, education and their interaction with the rate of change in parkinsonism [Estimate (Standard Error, p Value)].

ISSN: 1471-2318