Figure 7
From: Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
25OHC induction by immunostimulation or infection promotes cholesterol esterification and foam cell formation. (A) 25OHC is the only oxysterol induced by interferon (IFN) treatment or infection; panel from [309], with permission. (B) 25OHC stimulates cholesterol esterification in intact cells, from [316], with permission. (C) 25OHC is an allosteric effector of ACAT activity in insect cells expressing human ACAT, from [317] with permission; 7KC, 7-ketocholesterol; 6KCh, 6-ketocholestanol; 7αHC, 7α-hydroxycholesterol. (D) Treatment of bone marrow-derived macrophages with low-dose (ca. 0.1 μM) 25OHC, but not cholesterol itself, induces lipid body formation (BODIPY 493/503 fluorescence); scale bar 10 μm. From [318], with permission.