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Table 3 Multivariate-adjusted prevalence ratios for factors associated with restless legs syndrome* in the Health and Retirement Study 2002 survey (Nā€‰=ā€‰1008)

From: Restless legs syndrome and functional limitations among American elders in the Health and Retirement Study

Restless Leg Symptoms Predictor

Multivariate Adjusted Modelā€ 

Ā 

PR

95% CI

p

Age (reference: 50ā€“64ā€‰years)

Ā Ā Ā 

ā€ƒAge 65ā€“79ā€‰years

0.45

(0.28, 0.72)

<0.001

ā€ƒAge 80 or older

0.52

(0.25, 1.07)

0.07

Gender (reference: Male)

1.50

(0.93, 2.40)

0.10

Income (reference: Lowest Quartile)

Ā Ā Ā 

2nd quartile

1.37

(0.83, 2.27)

0.22

3rd quartile

0.82

(0.46, 1.46)

0.51

4th quartile

1.54

(0.85, 2.81)

0.16

Current drinking status (reference: None)

0.59

(0.37, 0.92)

0.02

Body Mass Index (reference: BMIā€‰<ā€‰25.0)

Ā Ā Ā 

BMI 25.0 ā€“ 29.9

1.77

(1.05, 2.99)

0.03

BMI 30 or greater

1.40

(0.80, 2.46)

0.24

Pain category (reference: None)

Ā Ā Ā 

Mild to moderate

2.67

(1.47, 4.84)

0.001

Severe

3.44

(2.00, 5.93)

<0.001

Number of chronic medications used (reference: None)

Ā Ā Ā 

1 chronic medication

1.14

(0.57, 2.26)

0.71

2 chronic medications

1.32

(0.70, 2.46)

0.39

3 or more chronic medications

2.54

(1.26, 5.12)

0.009

Out of pocket medical expenses (reference: Highest Quartile)

Ā Ā Ā 

2nd quartile

1.65

(0.88, 3.09)

0.12

3rd quartile

1.33

(0.69, 2.57)

0.40

4th quartile

2.12

(1.17, 3.86)

0.01

Frequency of doctor visits in last 2ā€‰years (reference: 0ā€“3 visits)

Ā Ā Ā 

4-7 visits

0.89

(0.43, 1.82)

0.74

8-11 visits

0.82

(0.46, 1.46)

0.50

12 or more visits

0.49

(0.27, 0.90)

0.02

Health limits ability to work

2.91

(1.75, 4.85)

<0.001

Falls in the last 2ā€‰years (reference: None)

Ā Ā Ā 

Fell once

1.33

(0.73, 2.40)

0.35

Fell 2 or more times

2.63

(1.49, 4.66)

<0.001

Associated sleep problems

Ā Ā Ā 

Problems with early waking

1.69

(1.09, 2.62)

0.02

Problems with frequent waking

1.55

(1.00, 2.41)

0.05

  1. Abbreviations: PRā€‰=ā€‰prevalence ratio; CIā€‰=ā€‰confidence interval; BMIā€‰=ā€‰Body Mass Index.
  2. * Restless Legs symptoms defined as unpleasant or restless sensations in the legs at least once per week, and reporting ā€œrestless, fidgety, or unable to sit stillā€ feelings at rest and the need to ā€œmove, rub, or stretch legsā€ (nā€‰=ā€‰104).
  3. ā€  Final multivariate model reflecting automated variable forward selection with improvements to Akaike Information Criterion statistic.