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Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12and folic acid on fracture incidence

  • Janneke P van Wijngaarden1Email author,
  • Rosalie AM Dhonukshe-Rutten1,
  • Natasja M van Schoor2,
  • Nathalie van der Velde3,
  • Karin MA Swart2,
  • Anke W Enneman3,
  • Suzanne C van Dijk3,
  • Elske M Brouwer-Brolsma1,
  • M Carola Zillikens4,
  • Joyce BJ van Meurs4,
  • Johannes Brug2,
  • André G Uitterlinden4,
  • Paul Lips5 and
  • Lisette CPGM de Groot1
BMC Geriatrics201111:80

DOI: 10.1186/1471-2318-11-80

Received: 16 September 2011

Accepted: 2 December 2011

Published: 2 December 2011

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
16 Sep 2011 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
21 Sep 2011 Author responded Author comments - Janneke van Wijngaarden
Resubmission - Version 3
21 Sep 2011 Submitted Manuscript version 3
9 Nov 2011 Author responded Author comments - Janneke van Wijngaarden
Resubmission - Version 4
9 Nov 2011 Submitted Manuscript version 4
30 Nov 2011 Author responded Author comments - Janneke van Wijngaarden
Resubmission - Version 5
30 Nov 2011 Submitted Manuscript version 5
1 Dec 2011 Author responded Author comments - Janneke van Wijngaarden
Resubmission - Version 6
1 Dec 2011 Submitted Manuscript version 6
Publishing
2 Dec 2011 Editorially accepted
2 Dec 2011 Article published 10.1186/1471-2318-11-80

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Human Nutrition, Wageningen University
(2)
Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University medical center
(3)
Department of Internal Medicine-Section Geriatric Medicine, Erasmus MC, University Medical Centre Rotterdam
(4)
Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam
(5)
Department of Endocrinology, VU University medical center

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