Table 1 Variables at baseline in the whole cohort not on warfarin and risk of definite VTE

Conventional risk factors

Age (years)

74.9 (3.1)

75.3 (3.4)

0.83 (0.54, 1.28)

0.39

Body mass index (kg/m²)

28.5 (5.2)

26.8 (4.2)

1.09 (1.02, 1.15)

0.0075

Total cholesterol (mmol/L)

5.5 (1.1)

5.7 (0.9)

0.80 (0.57, 1.10)

0.17

Triglyceride (mmol/L)

1.5 (0.9)

1.5 (0.7)

0.86 (0.56, 1.34)

0.51

LDL (mmol/L)

3.6 (0.9)

3.8 (0.8)

0.78 (0.54, 1.12)

0.18

HDL (mmol/L)

1.3 (0.4)

1.3 (0.3)

1.04 (0.89, 1.21)

0.65

Systolic blood pressure (mmHg)

147.7 (21.9)

154.7 (21.8)

0.74 (0.57, 0.97)

0.027

Diastolic blood pressure (mmHg)

83.2 (12.4)

83.8 (11.4)

0.96 (0.74, 1.23)

0.73

Men

22 (45.8)

2694 (47.9)

0.94 (0.53, 1.66)

0.83

Current smoker

12 (25.0)

1519 (27.0)

0.93 (0.48, 1.79)

0.82

History of vascular disease

History of hypertension

32 (66.7)

3493 (62.1)

1.22 (0.67, 2.22)

0.52

History of diabetes

5 (10.4)

603 (10.7)

1.00 (0.40, 2.53)

1.00

History of vascular disease

16 (33.3)

2446 (43.5)

0.66 (0.36, 1.20)

0.18

History of MI

7 (14.6)

722 (12.8)

1.19 (0.53, 2.65)

0.67

History of angina

13 (27.1)

1519 (27.0)

1.01 (0.54, 1.91)

0.97

History of CHD

15 (31.3)

1758 (31.2)

1.01 (0.55, 1.86)

0.97

History of claudication

2 (4.1)

371 (6.6)

0.63 (0.15, 2.58)

0.52

History of arterial surgery or amputation for vascular disease

2 (4.1)

312 (5.5)

0.75 (0.18, 3.10)

0.69

History of peripheral arterial disease

3 (6.3)

603 (10.7)

0.57 (0.18, 1.82)

0.34

History of stroke/TIA

4 (8.3)

615 (10.9)

0.75 (0.27, 2.10)

0.59

Disability and cognition

IADL score

13.6 (1.1)

13.6 (1.0)

0.93 (0.72, 1.19)

0.55

Mini mental state exam (MMSE) score

27.6 (1.6)

28.0 (1.6)

0.84 (0.71, 0.99)

0.034

Barthel index score

19.7 (0.7)

19.8 (0.7)

0.93 (0.66, 1.30)

0.66

Years in education

15.0 (2.0)

15.1 (2.0)

0.98 (0.85, 1.13)

0.76

Country of origin

Scotland

21 (43.8)

2466 (43.8)

4.26 (1.00, 18.21)

0.034

Ireland

25 (52.1)

2104 (37.4)

6.16 (1.46, 26.00)

Netherlands

2 (4.2)

1057 (18.8)

Referent

Drug treatment

Pravastatin treatment

28 (58.3)

2795 (49.7)

1.42 (0.80, 2.52)

0.23

Co-morbidities

Cancer during the study

11 (22.9)

415 (7.4)

4.58 (2.33, 9.01)

<0.0001

Inflammation

IL-6* (pg/ml)

2.8 (2.1)

2.6 (1.9)

1.21 (0.80, 1.85)

0.37

sICAM-1* (ng/mL)

358 (1.41)

372 (1.39)

0.74 (0.31, 1.76)

0.50

CRP* (mg/L)

3.6 (3.1)

3.1 (3.1)

1.16 (0.90, 1.50)

0.25

Leptin* (ng/mL)

16.9 (2.4)

13.4 (2.4)

1.34 (0.97, 1.85)

0.077

Lipids

Lp(a)* (mg/dL)

11.2 (2.8)

13.6 (3.5)

0.89 (0.71, 1.11)

0.30

Apo A1 (g/L)

1.3 (0.2)

1.3 (0.2)

0.92 (0.29, 2.97)

0.89

Apo B (g/L)

1.1 (0.2)

1.1 (0.2)

0.45 (0.12, 1.66)

0.23

Biochemistry

Glucose* (mmol/L)

5.2 (1.2)

5.3 (1.2)

0.58 (0.13, 2.58)

0.47

Creatinine (umol/L)

104.2 (23.5)

101.1 (22.3)

1.01 (0.99, 1.02)

0.33

Urea*(mmol/L)

5.7 (1.4)

6.1 (1.3)

0.45 (0.16, 1.24)

0.12

ALT* (U/L)

22.3 (1.5)

21.3 (1.5)

1.32 (0.69, 2.54)

0.40

AST*(U/L)

24.3 (1.3)

23.5 (1.4)

1.38 (0.59, 3.21)

0.45

Creatine Kinase* (U/L)

84.0 (1.6)

82.6 (1.6)

1.06 (0.60, 1.86)

0.84

Free T4* (nmol/L)

17.6 (1.2)

16.3 (1.2)

1.77 (0.61, 5.15)

0.30

TSH* (mU/L)

1.6 (2.0)

1.8 (2.4)

0.89 (0.66, 1.20)

0.45

Hematology

Hemoglobin (g/dL)

14.2 (1.2)

14.0 (1.2)

1.15 (0.92, 1.44)

0.22

Hematocrit (L/L)

0.4 (0.03)

0.4 (0.04)

1.22 (0.90, 1.65)

0.19