From: Hypothermia predicts mortality in critically ill elderly patients with sepsis
Variable | </= 65 years (n = 67) | > 65 years (n = 108) | P Value |
---|---|---|---|
Median age (IQR) | 56 (46-60) | 76 (71-79) | <0.01 |
Sex (M:F) | 27:40 | 66:42 | <0.01 |
Co-morbidities | |||
Chronic renal failure | 11 | 13 | 0.15** |
Chronic obstructive pulmonary disease | 13 | 25 | 0.83** |
Congestive cardiac failure/Ischemic heart disease/Hypertension | 27 | 69 | 0.05** |
Diabetes mellitus | 9 | 20 | 0.66** |
Physiological variables | Median (IQR) | Median (IQR) | |
PaO2 (torr) | 93 (67-126) | 101 (73.7-172.7) | 0.25 |
PaCO2(torr) | 41 (34-50) | 39 (32-49) | 0.59 |
HCO3 (mmol/L)* | 20.56 (4.09) | 17.97 (5.38) | <0.01 |
pH | 7.32 (7.25-7.41) | 7.29 (7.15-7.37) | 0.02 |
Heart rate | 110 (99-128) | 105 (88.5-120) | 0.02 |
Systolic blood pressure (mmHg) | 120 (95.5-141) | 138 (113.5-152) | <0.01 |
Diastolic blood pressure (mmHg) | 65 (51-72) | 62 (50-74) | 0.77 |
Mean blood pressure(mmHg) | 84 (67-95) | 87 (77-98) | 0.13 |
Temperature (degree Celsius) | 37.8 (37-38.5) | 37.2 (36.5-37.9) | <0.01 |
Respiratory rate | 26 (18.5-32.5) | 26 (20-30) | 0.28 |
Number of organs failed on admission | 1 (0-2) | 1 (0-2) | 0.10 |
Laboratory variables | |||
Sodium (mmol/L) | 142 (138.2-145.7) | 142 (139-145) | 0.71 |
Potassium (mmol/L) | 4.25 (0.84) | 4.50 (0.78) | 0.04 |
Urea (mmol/L) | 9 (5.2-15.8) | 14.5 (9.2-22.5) | <0.01 |
Creatinine (umol/L) | 80.5 (51.7-147.5) | 160 (100-250) | <0.01 |
Bilirubin (umol/L) | 14 (8.25-27) | 15.5 (8-27.5) | 0.93 |
Albumin (g/L) | 28.85 (7.39) | 29.27 (5.87) | 0.69 |
Blood sugar (mmol/L) | 7.8 (6.1-12.2) | 9.4 (6.7-12.2) | 0.23 |
C reactive protein (mg/L) | 197.6 (91.4-274.3) | 168.7 (62.3-253.5) | 0.28 |
Lactate (mmol/L) | 2.1 (1.4-4.3) | 2.8 (1.5-6.1) | 0.29 |
White cell count (×10^9/L) | 16.2 (11.3-20.9) | 15.2 (10.2-24) | 0.98 |
Hematocrit (%) | 0.30 (0.26-0.33) | 0.31(0.27-0.35) | 0.10 |
Positive culture in the first 24 hours (%) | 40.3 | 44.6 | 0.62 |
Scores | |||
APACHE III | 57 (41.2-70.2) | 77 (58.5-93) | <0.01 |
APACHE III without age component | 48 (36-65) | 57.5 (40.2-77.7) | 0.03 |
SAPS II | 34.5 (26.7-42) | 47 (39-56.5) | <0.01 |
SAPS II without age component | 27 (20-34) | 31 (22-41.5) | 0.01 |